ROLE OF GASTRIC-JUICE IN FEEDBACK-REGULATION OF RAT PANCREATIC-SECRETION BY LUMINAL PROTEASES

被引：9

作者：

GREEN, GM

机构：

[1] Department of Physiology, University of Texas Health Science Center, San Antonio, TX

来源：

PANCREAS | 1990年 / 5卷 / 04期

关键词：

Feedback regulation; Gastric juice; Pancreatic secretion; Trypsin inhibitors;

D O I：

10.1097/00006676-199007000-00012

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The role of gastric juice in the intestine on the pancreatic secretory response to intraduodenal infusion of trypsin inhibitors or to diversion of bile and pancreatic juice from the intestine was studied in conscious rats with pylorus ligation and gastric juice drainage. In absence of gastric juice in the intestine, diversion of bile and pancreatic juice from the intestine stimulated pancreatic secretion, but the incremental protein and fluid secretory responses to diversion of bile and pancreatic juice were increased approximately 2.9-fold and 2.5-fold, respectively, by intraduodenal infusion of HC1 (60 µEq/h). Intraduodenal infusion of HC1 (240 µEq/h) had no effect on the pancreatic secretory response to infusion of lima bean trypsin inhibitor (20 mg). These results support the hypothesis that the inhibitory effect of atropine on the pancreatic secretory response to diversion of pancreatic juice or bile and pancreatic juice is secondary to inhibition of gastric acid secretion. The lack of effect of HC1 on the pancreatic response to trypsin inhibitor contradicts the hypothesis that acid in the intestine is important or necessary for the feedback response to loss of intraluminal protease activity. It is proposed that acid in the intestine augments the pancreatic response to diversion of pancreatic juice or bile and pancreatic juice by reducing intraluminal pH and thereby inactivating residual pancreatic proteases. © 1990 Raven Press Ltd., New York.

引用

页码：445 / 451

页数：7

共 17 条

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