IDENTIFICATION OF AN AUTOCRINE NEGATIVE GROWTH-FACTOR - MOUSE BETA-GALACTOSIDE-BINDING PROTEIN IS A CYTOSTATIC FACTOR AND CELL-GROWTH REGULATOR

被引：263

作者：

WELLS, V

MALLUCCI, L

机构：

来源：

CELL | 1991年 / 64卷 / 01期

关键词：

D O I：

10.1016/0092-8674(91)90211-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Murine beta-galactoside-binding protein, a protein classified as a soluble lectin, is shown to be a cell growth-regulatory molecule and a cytostatic factor. The growth-inhibitory effect is not related to lectin properties, and competition assays indicate that the protein binds to specific cell surface receptors with high affinity. It exerts control in G0 and at G2, both as a regulator of cell replication and as a cytostatic factor.

引用

页码：91 / 97

页数：7

共 37 条

[1] EVIDENCE THAT THE 14 KDA SOLUBLE BETA-GALACTOSIDE-BINDING LECTIN IN MAN IS ENCODED BY A SINGLE GENE [J].