THE EFFECT OF GAMMA-LINOLENIC ACID, AN INVITRO CYTOSTATIC SUBSTANCE CONTAINED IN EVENING PRIMROSE OIL, ON PRIMARY LIVER-CANCER - A DOUBLE-BLIND PLACEBO CONTROLLED TRIAL

被引:22
作者
VANDERMERWE, CF
BOOYENS, J
JOUBERT, HF
VANDERMERWE, CA
机构
[1] MED UNIV S AFRICA,DIV GASTROENTEROL,MEDUNSA 0204,SOUTH AFRICA
[2] MED UNIV S AFRICA,DIV PHYSIOL,MEDUNSA 0204,SOUTH AFRICA
[3] MED UNIV S AFRICA,DIV CHEM PATHOL,MEDUNSA 0204,SOUTH AFRICA
[4] HF VERWOERD HOSP,S AFRICAN MRC,PRETORIA 0001,SOUTH AFRICA
来源
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1990年 / 40卷 / 03期
关键词
D O I
10.1016/0952-3278(90)90098-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The cytostatic effects of essential fatty acid metabolic intermediates and of some prostaglandins and leukotrienes in vitro have been extensively documented. The essential fatty acids (EFAs) exhibit no side-effects when taken as a dietary supplement, even in large doses. Primary Liver Cancer (PLC) is a fatal disease in our area as it is always multifocal in nature. In vitro studies have shown a cytostatic effect of gamma-linolenic acid (GLA) on primary liver cancer cells. In a double-blind placebo controlled trial, using Evening Primrose Oil (as a source of GLA) as a dietary supplement in PLC patients, no statistically significant effect was observed on survival time or liver size. There was however a statistical significant beneficial effect on Gamma Glutamyl transferase values as a measure of liver function. No side-effects were observed. The large size of tumour and the low doses of GLA used in this trial probably explain the lack of significant effect on survival times. © 1990.
引用
收藏
页码:199 / 202
页数:4
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