VISUOSPATIAL COGNITION IN HUNTINGTONS-DISEASE

被引：66

作者：

MOHR, E

BROUWERS, P

CLAUS, JJ

MANN, UM

FEDIO, P

CHASE, TN

机构：

[1] Medical Neurology Branch, Ninds, Bethesda, Maryland

[2] Pediatric Branch, NCI, Bethesda, Maryland

[3] Experimental Therapeutics Branch, Ninds, National Institutes of Health, Bethesda, Maryland

来源：

MOVEMENT DISORDERS | 1991年 / 6卷 / 02期

关键词：

Huntington's disease;

D O I：

10.1002/mds.870060207

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The notion of specificity of visuospatial dysfunction in Huntington's disease (HD) was evaluated in a sample of afflicted patients as a function of symptom duration, age at onset, and overall dementia severity. Factor analytic procedures indicated that overall visuospatial processing capacity (factor 1) as well as the ability for spatial manipulation (factor 3) was markedly affected in HD patients. In contrast, consistency of spatial judgment (factor 2) appeared to remain relatively intact in these patients. Age at onset seemed to have no relationship with any of these variables, whereas dementia severity demonstrated a significant relationship with overall visuospatial processing capacity. Most importantly, duration of symptoms was significantly associated with the declining ability to mentally perform spatial manipulations. The observation of circumscribed visuospatial impairment in HD patients may have important consequences for the further understanding of the neurobehavioral consequences of this disorder.

引用

页码：127 / 132

页数：6

共 28 条

[1]

Hayden MR., Huntington's chorea, (1981)

[2]

De La Monte SM, Vonsattel JP, Richardson EP., Morphometric demonstration of atrophic changes in cerebral cortex, white matter, and neostriatum in Huntington's disease, J Neuropathol Exp Neurol, 47, pp. 516-525, (1988)

[3]

Kuhl DE, Metter EJ, Riege WH, Markham CH., Patterns in cerebral glucose utilization in Parkinson's disease and Huntington's disease, Ann Neurol, 15, (1984)

[4]

Young AB, Penny JB, Starosta-Rubinstein S, Et al., PET scan investigations of Huntington's disease: cerebral metabolic correlates of neurological features and functional decline, Ann Neurol, 20, pp. 296-303, (1986)

[5]

Granholm E, Butters N., Associate encoding and retrieval in Alzheimer's and Huntington's disease, Brain and Cognition, 7, (1988)

[6]

Starkstein SE, Brandt J, Folstein S, Et al., Neuropsychological and neuroradiological correlates in Huntington's disease, J Neurol Neurosurgery Psychiatry, 51, pp. 1259-1263, (1988)

[7]

Saint-Cyr JA, Taylor AE, Lang AE., Procedural learning and neostriatal dysfunction in man, Brain, 11, pp. 941-959, (1988)

[8]

Weinberger DR, Berman KF, Iadarola M, Driesen N, Zec RF., Prefrontal cortical blood flow and cognitive function in Huntington's disease, J Neurol Neurosurgery Psychiatry, 51, pp. 94-104, (1988)

[9]

Goldberg TE, Berman KF, Mohr E, Weinberger DR., Regional cerebral blood flow and cognitive function in Huntington's disease and schizophrenia: a comparison of patients matched for performance on a prefrontal‐type task, Arch Neurol, 47, pp. 418-422, (1990)

[10]

Fedio P, Cox CS, Neophytides A, Canal-Frederick G, Chase TN., Neuropsychological profile of Huntington's disease: patients and those at risk, 23, pp. 239-255, (1979)

← 1 2 3 →