EFFECTS OF MPTP ON THE CEREBROVASCULATURE

被引：10

作者：

ADAMS, JD ^{[1
]}

KLAIDMAN, LK ^{[1
]}

ODUNZE, IN ^{[1
]}

JOHANNESSEN, JN ^{[1
]}

机构：

[1] NIH,BETHESDA,MD 20205

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 1991年 / 9卷 / 02期

关键词：

MPTP; BRAIN MICROVASCULATURE; BLOOD BRAIN BARRIER;

D O I：

10.1016/0736-5748(91)90006-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, has been shown to cause pooling of blood in the brain microvasculature and decrease the permeability of the blood-brain barrier. All areas of the brain examined in this study were affected. This study points out the possibility that reduced nutrient uptake, hypoxia and ensuing free radical damage are involved in the mechanism of toxicity of this neurotoxin.

引用

页码：155 / 159

页数：5

共 12 条

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