1,4-DIHYDROPYRIDINES FROM DITHIONITE REDUCTION OF PYRIDINIUM SALTS WITHOUT ELECTRON-WITHDRAWING GROUPS AS SUBSTITUENTS

被引：35

作者：

WONG, YS ^{[1
]}

MARAZANO, C ^{[1
]}

GNECCO, D ^{[1
]}

DAS, BC ^{[1
]}

机构：

[1] INST CHIM SUBST NAT,CNRS,F-91198 GIF SUR YVETTE,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(00)75796-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Conditions have been established for the sodium dithionite (Na2S2O4) reduction of pyridinium salts 1 lacking electron-withdrawing substituents to their corresponding 1,4-dihydropyridines (1,4-DHPs) 2, a reaction which was previously reported to fail. The importance of hydrophobic effects for this reduction to take place could be recognized from the results obtained. The present procedure offers a very convenient mute to a number of 1,4-DHPs 2, in particular, a series of chiral derivatives such as 5 and 9.

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页码：707 / 710

页数：4

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