A SIMPLE AND EFFECTIVE METHOD FOR THE REDUCTION OF ACYL SUBSTITUTED HETEROCYCLIC 1,3-DICARBONYL COMPOUNDS TO ALKYL DERIVATIVES BY ZINC - ACETIC-ACID - HYDROCHLORIC-ACID

被引：11

作者：

KAPPE, T

AIGNER, R

ROSCHGER, P

SCHNELL, B

STADLBAUER, W

机构：

[1] Organic Synthesis Group, Institute of Organic Chemistry, Karl-Franzens-University of Graz, A-8010 Graz

来源：

TETRAHEDRON | 1995年 / 51卷 / 47期

关键词：

D O I：

10.1016/0040-4020(95)00733-O

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Acyl-4-hydroxy-2(1H)-quinolones (1a-k) were reduced in good yields (66-97%) to 3-alkyl-4-hydroxy-2(1H)-quinolinones (2a-k) using zinc powder (particle size <45 mu M) in acetic acid/hydrochloric acid. This method could be transformed to 3-acetyl-4-hydroxy-coumarin (1l), 3-acetyl-4-hydroxy-2-pyranone (3a) and 3-acetyl-4-hydroxy-2(1H)-pyridinone (3b), which yielded the 3-ethyl derivatives 21, 4a and 4b, respectively.

引用

页码：12923 / 12928

页数：6

共 41 条

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