POSTOPERATIVE RADIOTHERAPY IN CARCINOMA OF THE CERVIX - TREATMENT RESULTS AND PROGNOSTIC FACTORS

被引：22

作者：

ATKOVAR, G ^{[1
]}

UZEL, O ^{[1
]}

OZSAHIN, M ^{[1
]}

KOCA, S ^{[1
]}

SAHINLER, I ^{[1
]}

OKKAN, S ^{[1
]}

UZEL, R ^{[1
]}

机构：

[1] UNIV ISTANBUL,CERRAHPASA FAC MED,DEPT RADIAT ONCOL,ISTANBUL,TURKEY

来源：

RADIOTHERAPY AND ONCOLOGY | 1995年 / 35卷 / 03期

关键词：

POSTOPERATIVE RADIOTHERAPY; PROGNOSTIC FACTORS; CERVIX;

D O I：

10.1016/0167-8140(95)01570-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In order to assess the role of postoperative radiotherapy and prognostic factors, 126 patients who were treated with radiotherapy after surgery for clinical early-stage carcinoma of the cervix were reviewed. All patients received external pelvic radiotherapy and 37 patients were treated with additional vaginal cuff irradiation. The 5-year overall survival, disease-free survival and locoregional control rates were 71.1, 69.9 and 78.1%, respectively. The 5-year disease-free survival rates were 40% for grade 3 vs. 75.4% for grade 1 tumours (p = 0.05), 76.5% for pathological stage IB versus 54.1% for pathological stage IIA (p = 0.04), 36.6% for node-positive patients versus 82.5% for node-negative patients (p = 0.0017), 54% for full thickness cervical invasion versus 100% superficial cervical invasion (p = 0.01), 34.8% for positive margins versus 78.1 for negative margins (p < 0.0001). After a multivariate analysis, tumour grade (p = 0.026) and presence of positive margins (p = 0.006) were found to independently influence the outcome. Grade II and III complication rate was 5.5% in all patients. In conclusion, postoperative radiotherapy should be used in patients treated with simple hysterectomy as well as those treated with radical hysterectomy with unfavorable pathological findings.

引用

页码：198 / 205

页数：8

共 24 条

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