The beta(1)-subunit is essential for modulation by protein kinase C of an human and a non-human L-type Ca2+ channel

被引:38
作者
Bouron, A [1 ]
Soldatov, NM [1 ]
Reuter, H [1 ]
机构
[1] UNIV BERN,DEPT PHARMACOL,CH-3010 BERN,SWITZERLAND
关键词
Xenopus oocyte; calcium channel; protein kinase C;
D O I
10.1016/0014-5793(95)01327-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have investigated in Xenopus oocytes the effects of phorbol ester-induced protein kinase C (PKC) stimulation on dihydropyridine (DHP)-insensitive and -sensitive Ca2+ channels. DHP-insensitive Ba2+ currents (I-Ba) were recorded from endogenous channels in non-injected oocytes and in oocytes injected with cRNAs encoding the auxiliary rabbit alpha(2)/delta and beta(1) Ca2+ channel subunits. A human alpha(1C) cRNA, injected alone or in combination with cRNAs of the auxiliary subunits, was used for studying DHP-sensitive I-Ba. We found that DHP-insensitive I-Ba was increased by 4 beta-phorbol 12-myristate 13-acetate (PMA), while DHP-sensitive I-Ba was decreased. In both cases, the effects depended only on the co-expression of the beta(1) subunit.
引用
收藏
页码:159 / 162
页数:4
相关论文
共 22 条
  • [1] VOLTAGE-DEPENDENT FACILITATION OF A NEURONAL ALPHA(1C) L-TYPE CALCIUM-CHANNEL
    BOURINET, E
    CHARNET, P
    TOMLINSON, WJ
    STEA, A
    SNUTCH, TP
    NARGEOT, J
    [J]. EMBO JOURNAL, 1994, 13 (21) : 5032 - 5039
  • [2] CASTELLANO A, 1993, J BIOL CHEM, V268, P3450
  • [3] CASTELLANO A, 1993, J BIOL CHEM, V268, P13259
  • [4] FUNCTIONAL SUBUNIT STRUCTURE OF VOLTAGE-GATED CALCIUM CHANNELS
    CATTERALL, WA
    [J]. SCIENCE, 1991, 253 (5027) : 1499 - 1500
  • [5] SITE-DIRECTED MUTAGENESIS OF VIRTUALLY ANY PLASMID BY ELIMINATING A UNIQUE SITE
    DENG, WP
    NICKOLOFF, JA
    [J]. ANALYTICAL BIOCHEMISTRY, 1992, 200 (01) : 81 - 88
  • [6] DOLPHIN AC, 1995, EXP PHYSIOL, V80, P1
  • [7] MOLECULAR-BASIS FOR CA2+ CHANNEL DIVERSITY
    HOFMANN, F
    BIEL, M
    FLOCKERZI, V
    [J]. ANNUAL REVIEW OF NEUROSCIENCE, 1994, 17 : 399 - 418
  • [8] AUXILIARY SUBUNITS OF VOLTAGE-GATED ION CHANNELS
    ISOM, LL
    DEJONGH, KS
    CATTERALL, WA
    [J]. NEURON, 1994, 12 (06) : 1183 - 1194
  • [9] DOUBLE-PULSE FACILITATION OF SMOOTH-MUSCLE ALPHA-1-SUBUNIT CA2+ CHANNELS EXPRESSED IN CHO CELLS
    KLEPPISCH, T
    PEDERSEN, K
    STRUBING, C
    BOSSEDOENECKE, E
    FLOCKERZI, V
    HOFMANN, F
    HESCHELER, J
    [J]. EMBO JOURNAL, 1994, 13 (11) : 2502 - 2507
  • [10] REGULATION AND MODULATION OF CALCIUM CHANNELS IN CARDIAC, SKELETAL, AND SMOOTH-MUSCLE CELLS
    MCDONALD, TF
    PELZER, S
    TRAUTWEIN, W
    PELZER, DJ
    [J]. PHYSIOLOGICAL REVIEWS, 1994, 74 (02) : 365 - 507