ELECTROCHEMICAL REDUCTION OF ARYLETHENYLPYRIDINIUM SALTS - RELATION TO STRUCTURE AND ANTHELMINTIC ACTIVITY

被引：6

作者：

AMES, JR

机构：

[1] Department of Chemistry, University of Michigan-Flint, Flint, Michigan

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1991年 / 80卷 / 03期

关键词：

D O I：

10.1002/jps.2600800321

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cyclic voltammetry data were obtained for a series of 1(1-)- and 1(2-arylethenyl)pyridinium salts. The 1(1-arylvinyl) salts exhibited more negative reduction potentials than their N-beta-styryl counterparts. Rationalizations of the reduction values are provided. Differences in reduction potentials within a series are discussed utilizing substituent constant effects. Correlations exist for the electrochemical data and anthelmintic activity.

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页码：293 / 295

页数：3

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