STIMULATION BY XANTHINE-OXIDASE OF 3T3 SWISS FIBROBLASTS AND HUMAN-LYMPHOCYTES

被引：18

作者：

STIRPE, F

HIGGINS, T

TAZZARI, PL

ROZENGURT, E

机构：

[1] IMPERIAL CANC RES FUND, LONDON WC2A 3PX, ENGLAND

[2] IST NAZL RIC CANC, IMMUNOGENET LAB, I-16132 GENOA, ITALY

来源：

EXPERIMENTAL CELL RESEARCH | 1991年 / 192卷 / 02期

关键词：

D O I：

10.1016/0014-4827(91)90086-A

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Xanthine oxidase stimulates [3H]thymidine incorporation by 3T3 cells even in the absence of any added xanthine, but in the presence of, and synergistically with, insulin or various other growth-stimulating factors. Optimal stimulation was obtained with 2-3 mU enzyme/ml and higher concentrations were toxic. Xanthine oxidase also stimulated human peripheral blood lymphocytes in the presence of phytohemagglutinin and xanthine. © 1991.

引用

页码：635 / 638

页数：4

共 22 条

[1] MODIFIERS OF FREE-RADICALS INHIBIT INVITRO THE ONCOGENIC ACTIONS OF X-RAYS, BLEOMYCIN, AND THE TUMOR PROMOTER 12-O-TETRADECANOYLPHORBOL 13-ACETATE [J].