ASSOCIATION OF HUMAN-IMMUNODEFICIENCY-VIRUS AND ANAL HUMAN PAPILLOMAVIRUS INFECTION AMONG HOMOSEXUAL MEN

被引:56
作者
CRITCHLOW, CW
HOLMES, KK
WOOD, R
KRUEGER, L
DUNPHY, C
VERNON, DA
DALING, JR
KIVIAT, NB
机构
[1] UNIV WASHINGTON,DEPT BIOSTAT,SEATTLE,WA 98195
[2] UNIV WASHINGTON,DEPT EPIDEMIOL,SEATTLE,WA 98195
[3] UNIV WASHINGTON,DEPT MED,SEATTLE,WA 98195
[4] UNIV WASHINGTON,DEPT PATHOL,SEATTLE,WA 98195
[5] SEATTLE KING CTY DEPT PUBL HLTH,SEATTLE,WA 98104
关键词
D O I
10.1001/archinte.152.8.1673
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background.-A previous study of men with proctitis, proctocolitis, or enteritis showed an association of anal human papillomavirus (HPV) infection with human immunodeficiency virus (HIV) infection. Because anorectal abnormalities may confound an observed association between anal HPV DNA and HIV seropositivity, the present study was undertaken among consecutive homosexual men seeking HIV serologic testing who were unselected for anorectal symptoms. Methods.-Consecutive homosexual men underwent a standardized interview, physical examination, and collection of specimens for HIV serologic testing and detection of anal HPV DNA. Results.-Anal HPV DNA was detected in eight (31 %) of 26 HIV-seropositive men and in 10 (8 %) of 119 HIV-seronegative men (odds ratio, 5.8; 95 % confidence interval, 1.1 to 30.1. adjusted for history of sexually transmitted disease, current anorectal symptoms, and age). When men with anorectal symptoms were excluded from the analysis, anal HPV DNA was detected in 27 % of seropositive men compared with 8% of,seronegative men (odds ratio, 4.4; 95% confidence interval 1.4 to 13.4). There was no difference between HIV-seropositive and HIV-seronegative men with respect to distribution of type of HPV DNA. Men with group II or III and group IV HIV disease were 4.1 and 10.9 times, respectively, more likely than HIV-seronegative men to have anal HPV DNA detected. Conclusions.-Because HIV-seropositive men appear to be at increased risk for the detection of anal HPV DNA, the natural course of anal HPV infection should be compared among HIV-seropositive and HIV-seronegative homosexual men.
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页码:1673 / 1676
页数:4
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