PREVENTION OF DIABETES IN THE NOD MOUSE - IMPLICATIONS FOR THERAPEUTIC INTERVENTION IN HUMAN-DISEASE

被引：113

作者：

BOWMAN, MA ^{[1
]}

LEITER, EH ^{[1
]}

ATKINSON, MA ^{[1
]}

机构：

[1] JACKSON LAB,BAR HARBOR,ME 04609

来源：

IMMUNOLOGY TODAY | 1994年 / 15卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0167-5699(94)90154-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The prevention of insulin-dependent diabetes (IDD) in humans remains an elusive goal, despite the broad spectrum of therapeutic interventions that prevent the development of IDD in the non-obese diabetic (NOD) mouse. Can an animal model in which spontaneous autoimmune pathology is interrupted so easily serve as an archetype for the design of clinical trials aimed at the prevention of IDD in humans? In this article, Mark Bowmans Edward Leiter and Mark Atkinson review the intervention strategies that prevent IDD in the NOD mouse and indicate why these studies may well be relevant to the prevention of IDD in humans.

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收藏

页码：115 / 120

页数：6

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