ALPHA-1-TRYPSIN IMMUNOREACTIVITY IN ALZHEIMERS-DISEASE

被引：26

作者：

SMITH, MA ^{[1
]}

KALARIA, RN ^{[1
]}

PERRY, G ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV,DEPT NEUROL,CLEVELAND,OH 44106

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 193卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.1663

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study is the initial demonstration of trypsin-like immunoreactivity within the human CNS. Using two monoclonal antibodies to α1-trypsin, we found trypsin-like immunoreactivity associated with the senile plaques of Alzheimer disease. Immunoblots prepared from homogenized Alzheimer and control cortex showed increased amounts of the 24,000Da α1-trypsin species in diseased compared to control tissue. We suggest an alteration in α1-trypsin protease regulation could be important in the formation of senile plaques and the pathogenesis of Alzheimer disease. © 1993 Academic Press, Inc.

引用

页码：579 / 584

页数：6

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