PRIMARY CULTURES OF RHESUS PLACENTAL SYNCYTIOTROPHOBLASTS ARE PERMISSIVE FOR SIV INFECTION

被引：5

作者：

GOLOS, TG ^{[1
]}

KRUGNERHIGBY, LA ^{[1
]}

WILLIAMS, CS ^{[1
]}

FISHER, JM ^{[1
]}

JOHNSON, KJ ^{[1
]}

DURNING, M ^{[1
]}

SCHULTZ, KT ^{[1
]}

机构：

[1] UNIV WISCONSIN,SCH VET MED,DEPT PATHOBIOL SCI,MADISON,WI 53706

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 1994年 / 23卷 / 2-3期

关键词：

PLACENTA; PREGNANCY; SIMIAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS-1; HOFBAUER CELL;

D O I：

10.1111/j.1600-0684.1994.tb00104.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Primary cultures of rhesus syncytiotrophoblasts incubated with SIV(deltaB670), SIV(mac251), or SIV(mac239) produced readily detectable virus in the supernatant for up to three weeks after infection. At four weeks, cells generally failed to release virus but placental cell lysates and placental cells cocultured for 24 hours with uninfected CEM x 174 cells were able to transmit infection. The presence of virus was confirmed by electron microscopy and PCR amplification of viral sequences from trophoblast genomic DNA. SIV p27 antigen was localized by immunostaining primarily in syncytiotrophoblasts.

引用

页码：66 / 74

页数：9

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