5HT2 RECEPTOR CHANGES IN MAJOR DEPRESSION

被引：248

作者：

YATES, M ^{[1
]}

LEAKE, A ^{[1
]}

CANDY, JM ^{[1
]}

FAIRBAIRN, AF ^{[1
]}

MCKEITH, IG ^{[1
]}

FERRIER, IN ^{[1
]}

机构：

[1] NEWCASTLE GEN HOSP,BRIGHTON CLIN,NEWCASTLE TYNE NE4 6BE,TYNE & WEAR,ENGLAND

来源：

BIOLOGICAL PSYCHIATRY | 1990年 / 27卷 / 05期

关键词：

D O I：

10.1016/0006-3223(90)90440-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The 5HT2 receptor has been studied using quantitative tritium film autoradiography in the postmortem frontal cortex of 15 cases suffering from major depression and controls, matched for age, gender, postmortem delay, and storage time. In unmedicated depressives there was a significant increase in 5HT2 receptor binding over matched control values. Antidepressant-treated depressives dying while depressed had 5HT2 receptor densities not significantly different from control values. Depressives dying euthymic (i.e., recovered) showed a marked reduction in 5HT2 receptor binding when compared with controls. A tentative hierarchy of 5HT2 receptors in affective states is proposed. © 1990.

引用

页码：489 / 496

页数：8

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