HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE SIMULTANEOUS DETERMINATION OF MONOETHYLGLYCINEXYLIDIDE AND LIGNOCAINE

被引：18

作者：

CHEN, Y

POTTER, JM

RAVENSCROFT, PJ

机构：

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 574卷 / 02期

关键词：

D O I：

10.1016/0378-4347(92)80054-T

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An accurate and sensitive high-performance liquid chromatographic method with UV detection was developed for the simultaneous measurement of monoethylglycinexylidide (MEGX) and lignocaine in human plasma and serum, using organic solvent extraction and trimethoprim (TMP) as an internal standard. The mean recoveries for MEGX, TMP and lignocaine were 86.1 +/- 3.7, 98.3 +/- 1.8 and 77.0 +/- 4.7%, respectively (n = 6). The relative standard deviations for MEGX concentrations of 10 and 200 ng/ml were < 4% and for lignocaine concentrations of 200 and 1200 ng/ml they were < 8%.

引用

收藏

页码：361 / 364

页数：4

相关论文

共 13 条

[1] A HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF DISOPYRAMIDE, LIDOCAINE AND THEIR MONODEALKYLATED METABOLITES [J].

ANGELO, HR ;

BONDE, J ;

KAMPMANN, JP ;

KASTRUP, J .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1986, 46 (07) :623-627

[2] HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC DETERMINATION OF LIDOCAINE AND ITS ACTIVE DEETHYLATED METABOLITES [J].

HILL, J ;

ROUSSIN, A ;

LELORIER, J ;

CAILLE, G .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1980, 69 (11) :1341-1343

[3] SIMULTANEOUS QUANTITATION OF LIDOCAINE AND ITS 4 METABOLITES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY - APPLICATION TO STUDIES ON INVITRO AND INVIVO METABOLISM OF LIDOCAINE IN RATS [J].

KAWAI, R ;

FUJITA, S ;

SUZUKI, T .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1985, 74 (11) :1219-1224

[4]

KUSHIDA K, 1984, CLIN CHEM, V30, P637

[5] SIMULTANEOUS DETERMINATION OF LIDOCAINE AND ITS METABOLITES IN PLASMA AND MYOCARDIUM [J].

LUZZI, FA ;

WENGER, TL ;

KLINGER, JK ;

BARCHOWSKY, A ;

STRAUSS, HC .

JOURNAL OF CHROMATOGRAPHY, 1984, 311 (02) :291-299

[6]

NARANG PK, 1978, CLIN PHARMACOL THER, V24, P654

[7] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE SIMULTANEOUS DETERMINATION OF LIDOCAINE AND ITS N-DEALKYLATED METABOLITES IN PLASMA [J].

NATION, RL ;

PENG, GW ;

CHIOU, WL .

JOURNAL OF CHROMATOGRAPHY, 1979, 162 (03) :466-473

[8]

OELLERICH M, 1987, J CLIN CHEM CLIN BIO, V25, P845

[9] LIDOCAINE METABOLITE FORMATION AS A MEASURE OF LIVER-FUNCTION IN PATIENTS WITH CIRRHOSIS [J].

OELLERICH, M ;

BURDELSKI, M ;

LAUTZ, HU ;

SCHULZ, M ;

SCHMIDT, FW ;

HERRMANN, H .

THERAPEUTIC DRUG MONITORING, 1990, 12 (03) :219-226

[10]

PROELSS HF, 1986, CLIN CHEM, V32, P1311