DRUG-OLIGONUCLEOTIDE CONJUGATES

被引：10

作者：

BYRN, SR

CARLSON, DV

CHEN, JK

CUSHMAN, MS

GOLDMAN, ME

MA, WP

PIDGEON, CL

RAY, KA

STOWELL, JG

WEITH, HL

机构：

[1] PURDUE UNIV,SCH PHARM & PHARM SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

[2] MERCK SHARP & DOHME LTD,DEPT NEW LEAD PHARMACOL,W POINT,PA 19486

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1991年 / 6卷 / 03期

关键词：

ACRIDINE - ATTACHED TO OLIGONUCLEOTIDES; ALKALOID - ATTACHED TO OLIGONUCLEOTIDES; ANTISENSE - OLIGONUCLEOTIDE-DRUG CONJUGATES; BENZOPHENANTHRIDINE; CONJUGATE - OLIGONUCLEOTIDES LINKED TO DRUGS; DRUG - OLIGONUCLEOTIDE CONJUGATES; INTERCALATOR - DRUG-OLIGONUCLEOTIDE CONJUGATES; LINKER - DRUGS ATTACHED TO OLIGONUCLEOTIDES; LIPOSOME - DELIVERY OF ANTISENSE OLIGONUCLEOTIDE CONJUGATES; OLIGONUCLEOTIDE - DRUG-LINKED ANTISENSE CONJUGATES; PHOSPHORAMIDITE; REVERSE TRANSCRIPTASE ASSAY;

D O I：

10.1016/0169-409X(91)90022-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this review, drug oligonucleotide conjugates synthesized and characterized in our laboratories will be discussed. An idealized view of a complex between an acridine-oligonucleotide conjugate and RNA is shown above. In addition, other related conjugates will be reviewed. The goal of this review is to establish that it is now feasible to synthesize a wide range of drug oligonucleotide conjugates. The testing of these molecules will provide important information on the pharmacological usefulness of targeting drugs to specific sequences using oligonucleotides.

引用

收藏

页码：287 / 308

页数：22

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