MERKEL CELL-CARCINOMA

被引：219

作者：

RATNER, D

NELSON, BR

BROWN, MD

JOHNSON, TM

机构：

[1] UNIV MICHIGAN,MED CTR,DEPT DERMATOL,ANN ARBOR,MI 48109

[2] UNIV MICHIGAN,MED CTR,DEPT OTORHINOLARYNGOL,ANN ARBOR,MI 48109

[3] UNIV MICHIGAN,MED CTR,DEPT SURG,DIV PLAST SURG,ANN ARBOR,MI 48109

[4] UNIV ROCHESTER,DEPT DERMATOL,ROCHESTER,NY 14627

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1993年 / 29卷 / 02期

关键词：

D O I：

10.1016/0190-9622(93)70159-Q

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Merkel cell carcinoma is a malignant neuroendocrine tumor with features of epithelial differentiation. Biologically aggressive, it may be difficult to diagnose and, particularly in its late stages, even more difficult to treat effectively. This article addresses what is known and what is still controversial about the histogenesis, diagnosis, and management of Merkel cell carcinoma and the structure and function of the Merkel cell from which it is believed to be derived. The incidence, clinical presentation and diagnosis, ultrastructure, immunocytochemistry, treatment, and prognosis of this tumor will be discussed.

引用

页码：143 / 156

页数：14

共 163 条

[1] MULTICENTRIC AMYLOID CONTAINING CUTANEOUS TRABECULAR CARCINOMA - CASE-REPORT WITH ULTRASTRUCTURAL-STUDY [J].