DEPRESSED CONCENTRATIONS OF OXYTOCIN AND CORTISOL IN CHILDREN WITH RECURRENT ABDOMINAL-PAIN OF NONORGANIC ORIGIN

被引:57
作者
ALFVEN, G
DELATORRE, B
UVNASMOBERG, K
机构
[1] KAROLINSKA INST, DEPT PHARMACOL, S-17177 STOCKHOLM, SWEDEN
[2] HUDDINGE HOSP, DEPT PAEDIAT, S-14186 HUDDINGE, SWEDEN
[3] KAROLINSKA INST, DEPT STRESS RES, S-17177 STOCKHOLM, SWEDEN
关键词
CORTISOL; OXYTOCIN; PROLACTIN; RECURRENT ABDOMINAL PAIN; STRESS;
D O I
10.1111/j.1651-2227.1994.tb12989.x
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The purpose of the present study was to measure plasma concentrations of oxytocin, cortisol and prolactin in children with recurrent abdominal pain of non-organic origin (RAP). Forty children with RAP and 34 controls, matched for age and sex, participated in the study. A blood sample was collected after an overnight fast in association with clinical examinations. Oxytocin, cortisol and prolactin levels were determined by radioimmunoassay (RIA). Oxytocin and cortisol concentrations in the children with RAP were found to be significantly reduced compared with those of the controls (approximately 24 versus 63 pmol/l for oxytocin and 160 versus 300 nmol/l for cortisol, respectively). The low oxytocin and cortisol levels persisted at a second examination 3 months later. No significant differences in the prolactin levels were observed between IAP and controls.
引用
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页码:1076 / 1080
页数:5
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