ESTROGEN-RECEPTOR STATUS AND DIETARY INTAKES IN BREAST-CANCER PATIENTS

被引：40

作者：

HARLAN, LC

COATES, RJ

BLOCK, G

GREENBERG, RS

ERSHOW, A

FORMAN, M

AUSTIN, DF

CHEN, V

HEYMSFIELD, SB

机构：

[1] Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD

[2] Division of Epidemiology, School of Public Health, Emory University, Atlanta, GA

[3] Division of Nutrition, Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Atlanta, GA

[4] Lipid Metabolism, Atherogenesis Branch, National Heart, Lung, and Blood Institute, Bethesda, MD

[5] Department of Health Services, Cancer Epidemiology Unit, Emeryville, CA

[6] Department of Pathology, Louisiana State University, New Orleans, LA

[7] St. Luke’s/Roosevelt Hospital, Weight Control Unit, New York, NY

[8] School of public Health, University of california, Berkeley, CA

来源：

EPIDEMIOLOGY | 1993年 / 4卷 / 01期

关键词：

BREAST NEOPLASMS; DIET; WOMEN; ESTROGEN RECEPTOR; RACE; BODY MASS; CARBOHYDRATES; DIETARY FAT; ORAL CONTRACEPTIVES; PARITY;

D O I：

10.1097/00001648-199301000-00006

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We used data from a study of racial differences in cancer patient survival to examine the association between estrogen receptor status and the intake of nutrients and food groups among 689 black and white women, ages 20-79, with breast cancer newly diagnosed in 1985 and 1986. We reviewed medical records and collected interview data, including a 34-item food frequency questionnaire. Consistent with published reports, we found positive estrogen receptor status to be positively associated with age and inversely associated with parity and oral contraceptive use. Whites were more likely than blacks to have estrogen receptor-positive tumors. We examined eight nutrients and six food groups in multivariate analyses for association with estrogen receptor status. After adjusting for age, race, usual body mass index, and parity, a high percentage of calories from fat was associated with estrogen receptor-positive cancer, and a high percentage of calories from carbohydrates was associated with estrogen receptor-negative breast cancer. These findings indicate that women with breast cancer who are on diets with a high percentage of calories from fat may be more likely to develop estrogen receptor-positive cancers.

引用

页码：25 / 31

页数：7

共 36 条

[1] Stanford J.L., Szklo M., Brinton L.A., Estrogen receptors and breast cancer, Epidemiol Rev, 8, pp. 42-59, (1986)
[2] Moolgavkar S.H., Day N.E., Stevens R.G., Two-stage model for carcinogenesis: Epidemiology of breast cancer in females, J Natl Cancer Inst, 65, pp. 559-569, (1980)
[3] Hislop T.G., Kan L., Coldman A.J., Band P.R., Brauer G., Influence of estrogen receptor status on dietary risk factors for breast cancer, Can Med Assoc J, 138, pp. 424-430, (1988)
[4] Verreault R., Brisson J., Deschenes L., Naud F., Meyer F., Belanger L., Dietary fat in relation to prognostic indicators in breast cancer, J Natl Cancer Inst, 80, pp. 819-825, (1988)
[5] Cooper J.A., Rohan T.E., McKCant E.L., Horsfall D.J., Tilley W.D., Risk factors for breast cancer by oestrogen receptor status: A population-based case-control study, Br J Cancer, 59, pp. 119-125, (1989)
[6] Goodwin P.J., Boyd N.F., Critical appraisal of the evidence that dietary fat intake is related to breast cancer risk in humans, J Natl Cancer Inst, 79, pp. 473-485, (1987)
[7] Goldin B.R., The metabolism of the intestinal microflora and its relationship to dietary fat, colon and breast cancer, Dietary Fat and Cancer, pp. 655-685, (1986)
[8] Hulka B.S., Dietary fat and breast cancer: Case-control and cohort studies, Prev Med, 18, pp. 180-193, (1989)
[9] Willett W., Nutritional Epidemiology, (1990)
[10] Anderson K.E., Kappas A.M., Conney H.L., Bradlow H.L., Fishman J., The influence of dietary protein and carbohydrate on the principal oxidative biotransformation of estradiol in normal subjects, J Clin Endocrinol Metab, 59, pp. 103-107, (1984)

← 1 2 3 4 →