COCRYSTALLIZATION OF THE CATALYTIC SUBUNIT OF THE SERINE THREONINE SPECIFIC PROTEIN PHOSPHATASE-1 FROM HUMAN IN COMPLEX WITH MICROCYSTIN LR

The catalytic subunit of the serine/threonine specific protein phosphatase 1 from human (molecular mass 37 KDa) has been co-crystallized in complex with the cyanobacterial toxin microcystin LR (molecular mass 1 kDa). The crystals diffract to a resolution of 2.8 å when exposed to synchrotron radiation and belong to space group P21212 with a = 109.5 å, b = 90.6 å, c = 38.7 å. There is one molecule of protein phosphatase 1 per asymmetric unit. The crystal form is suitable for the determination of the atomic structure of protein phosphatase 1. © 1994 Academic Press Limited.