7-OXO-10-ALPHA-CUCURBITADIENOL FROM THE SEEDS OF TRICHOSANTHES KIRILOWII AND ITS ANTIINFLAMMATORY EFFECT

被引：27

作者：

AKIHISA, T

YASUKAWA, K

KIMURA, Y

TAKIDO, M

KOKKE, WCMC

TAMURA, T

机构：

[1] ZYNAXIS CELL SCI INC,MALVERN,PA 19355

[2] NIHON UNIV,COLL PHARM,FUNABASHI,CHIBA 274,JAPAN

来源：

PHYTOCHEMISTRY | 1994年 / 36卷 / 01期

关键词：

TRICHOSANTHES KIRILOWII; CUCURBITACEAE; SEEDS; TRITERPENE; 7-OXO-10-ALPHA-CUCURBITADIENOL; ANTIOEDEMA; TPA-INDUCED EAR EDEMA;

D O I：

10.1016/S0031-9422(00)97029-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of a new triterpene isolated from the seeds of Trichosanthes kirilowii was determined to be 7-oxo-10 alpha-cucurbita-5,24-dien-3 beta-ol (7-oxo-10 alpha-cucurbitadienol) by spectral and chemical methods. 7-0xo-10 alpha-cucurbitadienol, and its acetyl and 24-dihydro derivatives showed marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation in mice. The 50% inhibitory dose of these compounds for TPA-induced inflammation (1 mu g ear(-1)) was 0.4-0.7 mg ear(-1).

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收藏

页码：153 / 157

页数：5

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