PITUITARY DOWN-REGULATION IN IVF CYCLES - IS IT NECESSARY TO USE STRICT CRITERIA

被引：13

作者：

CALHAZJORGE, C

LEAL, F

CORDEIRO, I

PROENCA, H

BARATA, M

PEREIRACOELHO, AM

机构：

[1] Human Reproduction Unit, Department of Obstetrics and Gynecology, Santa Maria's Hospital, Lisboa Codex, 1699, Av. Prof. Egas Moniz

[2] Department of Clinical Pathology, Santa Maria's Hospital, Lisbon

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 1995年 / 12卷 / 09期

关键词：

IN VITRO FERTILIZATION; BUSERELIN ACETATE; DEGREE OF PITUITARY SUPPRESSION; CYCLE OUTCOME;

D O I：

10.1007/BF02212585

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Purpose: In a retrospective study we have reviewed the data of 570 consecutive IVF cycles in which a GnRH agonist (GnRHa) was started in the early follicular phase (long protocol). Cycles were divided in groups according to estradiol levels before HMG administration: A, <20 pg/ml; B, 20 to 50 pg/ml; C, 51 to 100 pg/ml. Our objective was to determine if the degree of pituitary suppression had any effect on the ovarian response to stimulation by exogenous gonadotropins, and/or on the IVF outcome. Results: There were no significant differences in cycle cancellation rates, no. of days of stimulation and ampoules of HMG, serum estradiol after HMG, no. of oocytes retrieved and fertilization rates between groups. Pregnancy rates (19.4%, 21% and 31.8%/cycle, and 24.1%, 27.5% and 37.8%/embryo transfer, respectively) and live-birth rates (16.2%, 16.1% and 25.0%/cycle, 20.1%, 21.2% and 29.7%/embryo transfer, respectively) were also not significantly different, Conclusions: The degree of pituitary suppression had no effects on either the ovarian response to gonadotropins (including HMG requirements) or the overall IVF results.

引用

页码：615 / 619

页数：5

共 24 条

[1]

Porter R.N., Smith W., Craft I.L., Abdulwahid N.A., Jacobs H.S., Induction of ovulation for in vitro fertilization using Buserelin and gonadotropins, Lancet, 2, pp. 1284-1285, (1984)

[2]

Neveu S., Hedon B., Bringer J., Chinchole J.M., Arnal F., Humeau C., Cristol P., Viala J.L., Ovarian stimulation by a combination of gonadotropin-releasing hormone agonist and gonadotropins for in vitro fertilization, Fertil Steril, 47, pp. 639-643, (1987)

[3]

Fleming R., Coutts J.R.T., Induction of multiple follicular growth in normally menstruating women with endogenous gonadotropin suppression, Fertil Steril, 45, pp. 226-230, (1986)

[4]

Wildt L., Diedrich K., Vander Ven H., Al Hasami S., Hubner H., Klase R., Ovarian hyperstimulation for in-vitro fertilization controlled by GnRH agonist administrated in combination with human menopausal gonadotropins, Hum Reprod, 1, pp. 15-19, (1986)

[5]

Smitz J., Devroey P., Braeckmans P., Camus M., Khan I., Staessen C., VanWaesberghe L.V., Wisanto A., Van Steirteghem A.C., Management of failed cycles in an IVF/GIFT programme with the combination of a GnRh analogue and HMG, Hum Reprod, 2, pp. 309-314, (1987)

[6]

Serafini P., Stone B., Kerin J., Batzofin J., Quinn P., Marrs R.P., An alternate approach to controlled ovarian hyperstimulation in “poor responders”: pretreatment with gonadotropin-releasing hormone analog, Fertil Steril, 49, pp. 90-95, (1988)

[7]

Garcia J.E., Padilla S.L., Bayati J., Baramki T.A., Follicular phase gonadotropin-releasing hormone agonist and human gonadotropins: a better alternative for ovulation induction in in vitro fertilization, Fertil Steril, 53, pp. 302-305, (1990)

[8]

Hughes E.G., Fedorkow D.M., Daya S., Sagle M.A., Koppel P., Collins J.A., The routine use of gonadotropin-releasing hormone agonists prior to in vitro fertilization and gamete intrafallopian transfer: a meta-analysis of randomized controlled trials, Fertil Steril, 58, pp. 888-896, (1992)

[9]

Dimitry E.S., Bates S.A., Oskarsson T., Margara R., Winston R.M.L., Programming in vitro fertilization for a 5- or 3-day week, Fertil Steril, 55, pp. 934-938, (1991)

[10]

Horvath P.M., Styler M., Hammond J.M., Shelden R.M., Kemmann E., Exogenous gonadotropin requirements are increased in leuprolide suppressed women undergoing ovarian stimulation, Fertil Steril, 49, pp. 159-162, (1988)

← 1 2 3 →