ALTERNATIVE TRANSLATION INITIATION SITE USAGE RESULTS IN 2 FUNCTIONALLY DISTINCT FORMS OF THE GATA-1 TRANSCRIPTION FACTOR

被引：114

作者：

CALLIGARIS, R

BOTTARDI, S

COGOI, S

APEZTEGUIA, I

SANTORO, C

机构：

[1] Lab. Naz.-Consorzio I., 34012 Trieste

[2] Lab. Naz.-Consorizo I., Dipto. Biofis. Chim. delle M., 34012 Trieste

[3] Centro Investigaciones Biologicas, Havana

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 25期

关键词：

D O I：

10.1073/pnas.92.25.11598

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

GATA-1 is a zinc-finger transcription factor that plays a critical role in the normal development of hematopoietic cell lineages. In human and murine erythroid cells a previously undescribed 40-kDa protein is detected with GATA-1-specific antibodies. We show that the 40-kDa GATA-1 (GATA-1s) is produced by the use of an internal AUG initiation codon in the GATA-1 transcript. The GATA-1 proteins share identical binding activity and form heterodimers in erythroleukemic cells but differ in their transactivation potential and in their expression in developing mouse embryos.

引用

页码：11598 / 11602

页数：5

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