OVARIAN HORMONES REGULATE ALPHA(1)-ADRENOCEPTOR AND BETA-ADRENOCEPTOR INTERACTIONS IN FEMALE RAT PINEALOCYTES

被引：10

作者：

ALONSO, R ^{[1
]}

ABREU, P ^{[1
]}

FAJARDO, N ^{[1
]}

HERNANDEZDIAZ, F ^{[1
]}

DIAZCRUZ, A ^{[1
]}

HERNANDEZ, G ^{[1
]}

SANCHEZCRIADO, J ^{[1
]}

机构：

[1] UNIV CORDOBA,SCH MED,DEPT PHYSIOL,CORDOBA,SPAIN

来源：

NEUROREPORT | 1995年 / 6卷 / 02期

关键词：

CYCLIC AMP; ESTRADIOL; PROGESTERONE; ESTROUS CYCLE; ADRENOCEPTORS; PINEALOCYTES;

D O I：

10.1097/00001756-199501000-00030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE have examined the effects of alpha(1)- and beta-receptor activation on cyclic AMP (cAMP) accumulation in cultured pinealocytes from female ovariectomized rats, and from intact rats at proestrus treated with the antiestrogen Tamoxifen, the antiprogestagen RU486, or with both. Isoproterenol (a beta-agonist) significantly increased cAMP levels in pinealocytes from intact and ovariectomized rats. This response was considerably enhanced in pinealocytes from rats treated with RU486 or Tamoxifen alone, but not with both. Moreover, incubation of pinealocytes with isoproterenol together with phenylephrine (an alpha(1)-agonist) produced a synergistic effect in animals that had been ovariectomized, or that had received RU486, either alone or in combination with Tamoxifen. These results suggest that, in female rats, ovarian steroids may regulate the interactions between alpha 1- and beta-adrenergic receptors, and thus modulate pineal melatonin synthesis during the oestrous cycle through these mechanisms.

引用

页码：345 / 348

页数：4

共 15 条

[1]

ALONSO R, 1993, MELATONIN BIOSYNTHES, P73

[2] SUSPENSION CULTURE OF PINEALOCYTES - REGULATION OF N-ACETYLTRANSFERASE ACTIVITY [J].