CHANGES IN THE NS GENE OF NEUROVIRULENT STRAINS OF INFLUENZA AFFECT SPLICING

被引：7

作者：

WARD, AC

AZAD, AA

MCKIMMBRESCHKIN, JL

机构：

[1] UNIV MELBOURNE,RUSSELL GRIMWADE SCH BIOCHEM,PARKVILLE,VIC 3052,AUSTRALIA

[2] BIOMOLEC RES INST,PARKVILLE,VIC,AUSTRALIA

来源：

VIRUS GENES | 1995年 / 10卷 / 01期

关键词：

INFLUENZA A VIRUSES; NEUROVIRULENCE; NS GENE; SPLICING;

D O I：

10.1007/BF01724301

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The nonstructural (NS) gene has been identified as an accessory factor in determining neurovirulence for influenza A virus. The nucleotide sequence of the NS gene of the neurovirulent variant A/NWS/33 was determined and compared with its parent, A/WS/33. Alterations in the mRNA structure of the gene were observed that serve to mask the 3' splice site. Changes in this region were shown to correlate with reduced splicing of the NS gene in neurovirulent strains.

引用

页码：91 / 94

页数：4

共 22 条

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