LIPOLYTIC ACTION OF GLUCAGON-LIKE PEPTIDES IN ISOLATED RAT ADIPOCYTES

被引：79

作者：

RUIZGRANDE, C ^{[1
]}

ALARCON, C ^{[1
]}

MERIDA, E ^{[1
]}

VALVERDE, I ^{[1
]}

机构：

[1] FDN JIMENEZ DIAZ,CTR CSIC,DEPT METAB NUTR & HORMONAS,AVDA REYES CATOLICOS 2,E-28040 MADRID,SPAIN

来源：

PEPTIDES | 1992年 / 13卷 / 01期

关键词：

GLPS; ISOLATED ADIPOCYTES; LIPOLYSIS; CYCLIC AMP PRODUCTION; GLYCEROL RELEASE;

D O I：

10.1016/0196-9781(92)90134-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lipolytic effect of GLP-1(1-36)-amide, GLP-1(7-36) amide and GLP-2 [proglucagon(126-159)] has been studied in isolated rat adipocytes. Glycerol release and cyclic AMP content were measured after incubation of adipocytes with GLPs and results have been compared with those obtained in the presence of glucagon. GLP-1(7-36)-amide and GLP-1(1-36)-amide at 10(-8), 10(-7) and 10(-6) M concentrations activated glycerol release, the truncated peptide having a more potent effect. On the other hand, GLP-2 had no effect on glycerol release. Also, it has been found that 10(-6) M GLP-1(7-36)-amide increases cyclic AMP content in adipocytes and does not compete with glucagon binding. These results demonstrate that GLP-1(7-36)-amide has a lipolytic effect on isolated rat adipocytes through different receptors than glucagon.

引用

页码：13 / 16

页数：4

共 28 条

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