ACTIONS OF INTERLEUKIN-4 ON PROSTAGLANDIN BIOSYNTHESIS AT THE CHORION-DECIDUAL INTERFACE

被引:20
作者
ADAMSON, S [1 ]
EDWIN, SS [1 ]
LAMARCHE, S [1 ]
MITCHELL, MD [1 ]
机构
[1] UNIV UTAH,SCH MED,DEPT OBSTET & GYNECOL,50 N MED DR,SALT LAKE CITY,UT 84132
关键词
INTERLEUKIN-4; PROSTAGLANDINS; CYTOKINES; PRETERM LABOR;
D O I
10.1016/0002-9378(93)90416-G
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: We determined the effects of interleukin-4 on chorion and decidual prostaglandin production. STUDY DESIGN: Chorion and decidual cells from term placentas were grown to confluence. Cells were then incubated with interleukin-4 either alone or with other known stimulants of prostaglandin production: interleukin-1beta, epidermal growth factor, ionomycin, or phorbol 12-myristate 13-acetate. Prostaglandin E2 production was determined with a specific radioimmunoassay. RESULTS: Interleukin-4 alone stimulated prostaglandin E2 production in chorion and decidual cells. Interleukin-4 significantly enhanced the stimulatory actions of phorbol 12-myristate 13-acetate, ionomycin, and epidermal growth factor but not interleukin-1beta on prostaglandin E2 production. CONCLUSION: Interleukin-4 stimulates prostaglandin E2 production by chorion and decidual cells. These data suggest that interleukin-4 production by immune effector cells in gestational tissues may contribute to the pathophysiologic features of preterm labor.
引用
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页码:1442 / 1447
页数:6
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