ACTIONS OF INTERLEUKIN-4 ON PROSTAGLANDIN BIOSYNTHESIS AT THE CHORION-DECIDUAL INTERFACE
被引:20
作者:
ADAMSON, S
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UNIV UTAH,SCH MED,DEPT OBSTET & GYNECOL,50 N MED DR,SALT LAKE CITY,UT 84132UNIV UTAH,SCH MED,DEPT OBSTET & GYNECOL,50 N MED DR,SALT LAKE CITY,UT 84132
ADAMSON, S
[1
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EDWIN, SS
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UNIV UTAH,SCH MED,DEPT OBSTET & GYNECOL,50 N MED DR,SALT LAKE CITY,UT 84132UNIV UTAH,SCH MED,DEPT OBSTET & GYNECOL,50 N MED DR,SALT LAKE CITY,UT 84132
EDWIN, SS
[1
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LAMARCHE, S
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UNIV UTAH,SCH MED,DEPT OBSTET & GYNECOL,50 N MED DR,SALT LAKE CITY,UT 84132UNIV UTAH,SCH MED,DEPT OBSTET & GYNECOL,50 N MED DR,SALT LAKE CITY,UT 84132
LAMARCHE, S
[1
]
MITCHELL, MD
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UNIV UTAH,SCH MED,DEPT OBSTET & GYNECOL,50 N MED DR,SALT LAKE CITY,UT 84132UNIV UTAH,SCH MED,DEPT OBSTET & GYNECOL,50 N MED DR,SALT LAKE CITY,UT 84132
MITCHELL, MD
[1
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机构:
[1] UNIV UTAH,SCH MED,DEPT OBSTET & GYNECOL,50 N MED DR,SALT LAKE CITY,UT 84132
OBJECTIVE: We determined the effects of interleukin-4 on chorion and decidual prostaglandin production. STUDY DESIGN: Chorion and decidual cells from term placentas were grown to confluence. Cells were then incubated with interleukin-4 either alone or with other known stimulants of prostaglandin production: interleukin-1beta, epidermal growth factor, ionomycin, or phorbol 12-myristate 13-acetate. Prostaglandin E2 production was determined with a specific radioimmunoassay. RESULTS: Interleukin-4 alone stimulated prostaglandin E2 production in chorion and decidual cells. Interleukin-4 significantly enhanced the stimulatory actions of phorbol 12-myristate 13-acetate, ionomycin, and epidermal growth factor but not interleukin-1beta on prostaglandin E2 production. CONCLUSION: Interleukin-4 stimulates prostaglandin E2 production by chorion and decidual cells. These data suggest that interleukin-4 production by immune effector cells in gestational tissues may contribute to the pathophysiologic features of preterm labor.