CRYSTALLIZATION INDUCED ASYMMETRIC TRANSFORMATION - SYNTHESIS OF D-P-HYDROXYPHENYLGLYCINE

被引：12

作者：

BHATTACHARYA, A

ARAULLOMCADAMS, C

MEIER, MB

机构：

[1] Hoechst Celanese Corporation, Corpus Christi Technical Center, Corpus Christi, Texas 78469

来源：

SYNTHETIC COMMUNICATIONS | 1994年 / 24卷 / 17期

关键词：

D O I：

10.1080/00397919408010553

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

D-p-hydroxyphenylglycine (D-HPG) is prepared from racemic HPG via salicylaldehyde mediated resolution-racemization of the corresponding D-3-bromocamphor-8-sulfonate salt in acetic acid. After slurry purification to improve the de to >99.9%, the crystallized salt is neutralized to produce D-HPG in 92% overall yield and 99.9% ee.

引用

页码：2449 / 2459

页数：11

共 26 条

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