GABA(B) RECEPTOR ANTAGONIST CGP-35348 SHORTENS TRANSCALLOSAL RESPONSE LATENCY OF PYRAMIDAL TRACT NEURONS

被引：6

作者：

CHOWDHURY, SA

KAWASHIMA, T

KONISHI, T

NIWA, M

MATSUNAMI, K

机构：

[1] GIFU UNIV,SCH MED,INST EQUILIBRIUM RES,GIFU 500,JAPAN

[2] GIFU UNIV,SCH MED,DEPT PHARMACOL,GIFU 500,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 285卷 / 01期

关键词：

GABA(B) RECEPTOR ANTAGONIST; CGP; 35348; PYRAMIDAL TRACT NEURON; TRANSCALLOSAL RESPONSE; CAT; MOTOR CORTEX;

D O I：

10.1016/0014-2999(95)00483-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of a specific GABA(B) receptor antagonist, p-(3-aminopropyl)-p-diethoxymethyl-phosphonic acid (CGP 35348), on pyramidal tract neuron responses to transcallosal stimulation were investigated in the cat motor cortex in vivo. Iontophoretic application of CGP 35348 significantly increased the number of spikes from 10.3 +/- 4.4 (control; n = 27; mean +/- S.D.) to 16.7 +/- 7.2 (CGP 35348) for 20 transcallosal stimulation trials, while the latency of neuronal activity was significantly shortened from 4.4 +/- 2.1 ms (control; n = 27; mean +/- S.D.) to 3.8 +/- 1.7 ms (CGP 35348). Tn conclusion, CGP 35348 facilitated transcallosal synaptic transmission between pyramidal tract neurons by removal of GABA(B) inhibition.

引用

页码：99 / 102

页数：4

共 15 条

[1] BITTIGER H, 1990, GABAB RECEPTORS IN MAMMALIAN FUNCTION, P47
[2] (-) BACLOFEN DECREASES NEUROTRANSMITTER RELEASE IN THE MAMMALIAN CNS BY AN ACTION AT A NOVEL GABA RECEPTOR
BOWERY, NG
HILL, DR
HUDSON, AL
DOBLE, A
MIDDLEMISS, DN
SHAW, J
TURNBULL, M
[J]. NATURE, 1980, 283 (5742) : 92 - 94
[3] BOWERY NG, 1990, GABAB RECEPTOR MAMMA, P442
[4] A PHYSIOLOGICAL-ROLE FOR GABAB RECEPTORS IN THE CENTRAL NERVOUS-SYSTEM
DUTAR, P
NICOLL, RA
[J]. NATURE, 1988, 332 (6160) : 156 - 158
[5] REDUCTION BY BACLOFEN OF MONO-SYNAPTIC EPSPS IN LUMBOSACRAL MOTONEURONES OF THE ANESTHETIZED CAT
EDWARDS, FR
HARRISON, PJ
JACK, JJB
KULLMANN, DM
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1989, 416 : 539 - 556
[6] EVARTS EV, 1965, J NERUOPHYSIOL, V29, P1011
[7] RECEPTOR SUBTYPES INVOLVED IN CALLOSALLY-INDUCED POSTSYNAPTIC POTENTIALS IN RAT FRONTAL AGRANULAR CORTEX INVITRO
KAWAGUCHI, Y
[J]. EXPERIMENTAL BRAIN RESEARCH, 1992, 88 (01) : 33 - 40
[8] KERR DIB, 1990, GABAB RECEPTORS MAMM, P27
[9] EFFECTS OF STIMULATION OF CORPUS-CALLOSUM ON PRECENTRAL NEURON ACTIVITY IN THE AWAKE MONKEY
MATSUNAMI, K
HAMADA, I
[J]. JOURNAL OF NEUROPHYSIOLOGY, 1984, 52 (04) : 676 - 691
[10] CGP 35348 - A CENTRALLY ACTIVE BLOCKER OF GABA-B RECEPTORS
OLPE, HR
KARLSSON, G
POZZA, MF
BRUGGER, F
STEINMANN, M
VANRIEZEN, H
FAGG, G
HALL, RG
FROESTL, W
BITTIGER, H
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 187 (01) : 27 - 38

← 1 2 →