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A QUANTITATIVE HISTOLOGICAL STUDY OF EARLY CLINICAL AND PRECLINICAL ALZHEIMERS-DISEASE
被引:63
作者
:
HUBBARD, BM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT PATHOL,DUNDEE DD1 9SY,SCOTLAND
HUBBARD, BM
FENTON, GW
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT PATHOL,DUNDEE DD1 9SY,SCOTLAND
FENTON, GW
ANDERSON, JM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT PATHOL,DUNDEE DD1 9SY,SCOTLAND
ANDERSON, JM
机构
:
[1]
UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT PATHOL,DUNDEE DD1 9SY,SCOTLAND
[2]
UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT PSYCHIAT,DUNDEE DD1 9SY,SCOTLAND
来源
:
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
|
1990年
/ 16卷
/ 02期
关键词
:
Alzheimer's disease;
neurofibrillary tangles;
neuronal depopulation;
subclinical change;
D O I
:
10.1111/j.1365-2990.1990.tb00940.x
中图分类号
:
R74 [神经病学与精神病学];
学科分类号
:
摘要
:
Brains from 70 unselected general hospital necropsy cases aged. 60–95 years were surveyed histologically for changes of Alzheimer's disease using Congo Red‐Gallocyanin preparations. Counts were made of neurofibrillary tangles in two areas of the neocortex, the hippocampal formation and the substantia innominata. Neurons were counted in the subiculum of the hippocampus, the substantia innominata and the locus coeruleus. In addition, a retrospective enquiry was made concerning the mental health of the patients in the study; cognitive performance was graded on the Global Deterioration Scale (GDS 1–7). Four cases (5.7%) had clinical and pathological changes amounting to early Alzheimer's disease. Tangles were very numerous in all areas and there was a 30% deficit or more of neurons in at least two of the structures counted. Although the diagnosis of Alzheimer's disease was not recorded during life, all had shown signs of early cognitive decline (GDS grades 3–6). A further six cases (8.6%) showed excessive tangle accumulation which may represent preclinical Alzheimer's disease. Tangles were present in the temporal neocortex (Brodmann area 22), whereas they were absent in the remainder of the survey. Tangle density in the hippocampal formation (>50 tangles in a 10 μm section) was also above the baseline level of the majority of cases. However, neuron loss was not widespread in these cases and none had shown evidence of cognitive impairment. The findings confirm that the early stages of Alzheimer's disease commonly occur amongst general hospital necropsies. The emergence of clinical signs of dementia appears to be related to the loss of a critical volume of neurons and not to tangle accumulation alone. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码:111 / 121
页数:11
相关论文
共 14 条
[1]
CARRASCO LH, 1986, LANCET, V1, P1388
[2]
QUANTITATIVE HISTOLOGICAL STUDIES ON AGED HUMAN BRAIN .1. SENILE PLAQUES AND NEUROFIBRILLARY TANGLES IN NORMAL PATIENTS
DAYAN, AD
论文数:
0
引用数:
0
h-index:
0
DAYAN, AD
[J].
ACTA NEUROPATHOLOGICA,
1970,
16
(02)
: 85
-
&
[3]
A QUANTITATIVE STUDY OF CEREBRAL ATROPHY IN OLD-AGE AND SENILE DEMENTIA
HUBBARD, BM
论文数:
0
引用数:
0
h-index:
0
HUBBARD, BM
ANDERSON, JM
论文数:
0
引用数:
0
h-index:
0
ANDERSON, JM
[J].
JOURNAL OF THE NEUROLOGICAL SCIENCES,
1981,
50
(01)
: 135
-
145
[4]
THE TOPOGRAPHIC DISTRIBUTION OF SENILE PLAQUES AND NEUROFIBRILLARY TANGLES IN THE BRAINS OF NONDEMENTED PERSONS OF DIFFERENT AGES
MANN, DMA
论文数:
0
引用数:
0
h-index:
0
MANN, DMA
TUCKER, CM
论文数:
0
引用数:
0
h-index:
0
TUCKER, CM
YATES, PO
论文数:
0
引用数:
0
h-index:
0
YATES, PO
[J].
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY,
1987,
13
(02)
: 123
-
139
[5]
MARSDEN CD, 1982, LANCET, V2, P1141
[6]
SENILE DEGENERATIVE BRAIN LESIONS AND DEMENTIA
MORIMATSU, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV GUNMA,SCH MED,INST NEUROL & REHABILIT,SHOWA MACHI 3 39 22,MAEBASHI CITY,GUNMA,JAPAN
MORIMATSU, M
HIRAI, S
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV GUNMA,SCH MED,INST NEUROL & REHABILIT,SHOWA MACHI 3 39 22,MAEBASHI CITY,GUNMA,JAPAN
HIRAI, S
MURAMATSU, A
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV GUNMA,SCH MED,INST NEUROL & REHABILIT,SHOWA MACHI 3 39 22,MAEBASHI CITY,GUNMA,JAPAN
MURAMATSU, A
YOSHIKAWA, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV GUNMA,SCH MED,INST NEUROL & REHABILIT,SHOWA MACHI 3 39 22,MAEBASHI CITY,GUNMA,JAPAN
YOSHIKAWA, M
[J].
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY,
1975,
23
(09)
: 390
-
406
[7]
Peress N S, 1973, Prog Brain Res, V40, P473
[8]
REISBERG B, 1982, AM J PSYCHIAT, V139, P1136
[9]
PARKINSONS-DISEASE AND ALZHEIMERS-DISEASE AS DISORDERS OF THE ISODENDRITIC CORE
ROSSOR, MN
论文数:
0
引用数:
0
h-index:
0
机构:
ADDENBROOKES HOSP,DEPT NEUROL SURG & NEUROL,CAMBRIDGE CB2 2QQ,ENGLAND
ADDENBROOKES HOSP,DEPT NEUROL SURG & NEUROL,CAMBRIDGE CB2 2QQ,ENGLAND
ROSSOR, MN
[J].
BRITISH MEDICAL JOURNAL,
1981,
283
(6306)
: 1588
-
1590
[10]
SCREENING FOR NEUROFIBRILLARY TANGLES AND ARGYROPHILIC PLAQUES WITH CONGO-RED AND POLARIZED-LIGHT
STOKES, MI
论文数:
0
引用数:
0
h-index:
0
机构:
NATL HOSP NERVOUS DIS,LONDON,ENGLAND
NATL HOSP NERVOUS DIS,LONDON,ENGLAND
STOKES, MI
TRICKEY, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
NATL HOSP NERVOUS DIS,LONDON,ENGLAND
NATL HOSP NERVOUS DIS,LONDON,ENGLAND
TRICKEY, RJ
[J].
JOURNAL OF CLINICAL PATHOLOGY,
1973,
26
(03)
: 241
-
242
←
1
2
→
共 14 条
[1]
CARRASCO LH, 1986, LANCET, V1, P1388
[2]
QUANTITATIVE HISTOLOGICAL STUDIES ON AGED HUMAN BRAIN .1. SENILE PLAQUES AND NEUROFIBRILLARY TANGLES IN NORMAL PATIENTS
DAYAN, AD
论文数:
0
引用数:
0
h-index:
0
DAYAN, AD
[J].
ACTA NEUROPATHOLOGICA,
1970,
16
(02)
: 85
-
&
[3]
A QUANTITATIVE STUDY OF CEREBRAL ATROPHY IN OLD-AGE AND SENILE DEMENTIA
HUBBARD, BM
论文数:
0
引用数:
0
h-index:
0
HUBBARD, BM
ANDERSON, JM
论文数:
0
引用数:
0
h-index:
0
ANDERSON, JM
[J].
JOURNAL OF THE NEUROLOGICAL SCIENCES,
1981,
50
(01)
: 135
-
145
[4]
THE TOPOGRAPHIC DISTRIBUTION OF SENILE PLAQUES AND NEUROFIBRILLARY TANGLES IN THE BRAINS OF NONDEMENTED PERSONS OF DIFFERENT AGES
MANN, DMA
论文数:
0
引用数:
0
h-index:
0
MANN, DMA
TUCKER, CM
论文数:
0
引用数:
0
h-index:
0
TUCKER, CM
YATES, PO
论文数:
0
引用数:
0
h-index:
0
YATES, PO
[J].
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY,
1987,
13
(02)
: 123
-
139
[5]
MARSDEN CD, 1982, LANCET, V2, P1141
[6]
SENILE DEGENERATIVE BRAIN LESIONS AND DEMENTIA
MORIMATSU, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV GUNMA,SCH MED,INST NEUROL & REHABILIT,SHOWA MACHI 3 39 22,MAEBASHI CITY,GUNMA,JAPAN
MORIMATSU, M
HIRAI, S
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV GUNMA,SCH MED,INST NEUROL & REHABILIT,SHOWA MACHI 3 39 22,MAEBASHI CITY,GUNMA,JAPAN
HIRAI, S
MURAMATSU, A
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV GUNMA,SCH MED,INST NEUROL & REHABILIT,SHOWA MACHI 3 39 22,MAEBASHI CITY,GUNMA,JAPAN
MURAMATSU, A
YOSHIKAWA, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV GUNMA,SCH MED,INST NEUROL & REHABILIT,SHOWA MACHI 3 39 22,MAEBASHI CITY,GUNMA,JAPAN
YOSHIKAWA, M
[J].
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY,
1975,
23
(09)
: 390
-
406
[7]
Peress N S, 1973, Prog Brain Res, V40, P473
[8]
REISBERG B, 1982, AM J PSYCHIAT, V139, P1136
[9]
PARKINSONS-DISEASE AND ALZHEIMERS-DISEASE AS DISORDERS OF THE ISODENDRITIC CORE
ROSSOR, MN
论文数:
0
引用数:
0
h-index:
0
机构:
ADDENBROOKES HOSP,DEPT NEUROL SURG & NEUROL,CAMBRIDGE CB2 2QQ,ENGLAND
ADDENBROOKES HOSP,DEPT NEUROL SURG & NEUROL,CAMBRIDGE CB2 2QQ,ENGLAND
ROSSOR, MN
[J].
BRITISH MEDICAL JOURNAL,
1981,
283
(6306)
: 1588
-
1590
[10]
SCREENING FOR NEUROFIBRILLARY TANGLES AND ARGYROPHILIC PLAQUES WITH CONGO-RED AND POLARIZED-LIGHT
STOKES, MI
论文数:
0
引用数:
0
h-index:
0
机构:
NATL HOSP NERVOUS DIS,LONDON,ENGLAND
NATL HOSP NERVOUS DIS,LONDON,ENGLAND
STOKES, MI
TRICKEY, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
NATL HOSP NERVOUS DIS,LONDON,ENGLAND
NATL HOSP NERVOUS DIS,LONDON,ENGLAND
TRICKEY, RJ
[J].
JOURNAL OF CLINICAL PATHOLOGY,
1973,
26
(03)
: 241
-
242
←
1
2
→