EFFECT OF SOME PEROXISOME PROLIFERATORS ON TRANSFORMING GROWTH FACTOR-BETA(1) GENE-EXPRESSION AND INSULIN-LIKE GROWTH-FACTOR II/MANNOSE-6-PHOSPHATE RECEPTOR GENE-EXPRESSION IN RAT-LIVER

被引：33

作者：

RUMSBY, PC ^{[1
]}

DAVIES, MJ ^{[1
]}

PRICE, RJ ^{[1
]}

LAKE, BG ^{[1
]}

机构：

[1] BIBRA TOXICOL INT,CARSHALTON SM5 4DS,SURREY,ENGLAND

来源：

CARCINOGENESIS | 1994年 / 15卷 / 02期

关键词：

D O I：

10.1093/carcin/15.2.419

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Male Sprague-Dawley rats were given daily oral doses of either corn oil (control), 80 mg/kg nafenopin (NAF), 50 mg/kg methylclofenapate (MCP), 50 mg/kg Wy-14,643 (WY) or 250 mg/kg clofibric acid (CA) for 7 days. Ah four compounds increased relative liver weight and produced hepatic peroxisome proliferation as assessed by induction of both peroxisomal (palmitoyl-CoA oxidation) and microsomal (lauric acid 12-hydroxylase) fatty acid oxidising enzyme activities. RNA was extracted from liver samples and analysed for expression of transforming growth factor-beta(1) (TGF-beta(1)) and the insulin-like growth factor II/mannose-6-phosphate (IGFII/Man6P) receptor (which may be involved in transporting latent TGF-beta(1) into hepatocytes). TGF-beta(1) mRNA levels were increased to 151-178% of control by all four compounds, whereas NAF, MCP and WY, but not CA, increased IGFII/Man6P receptor mRNA levels to 195-209% of control. The induction of TGF-beta(1) and IGFII/Man6P receptor expression by short term treatment with peroxisome proliferators may represent an adaptive response to limit the initial hyperplastic effects of such compounds.

引用

页码：419 / 421

页数：3

共 27 条

[1] COMPARISON OF THE ACUTE AND CHRONIC MITOGENIC EFFECTS OF THE PEROXISOME PROLIFERATORS METHYLCLOFENAPATE AND CLOFIBRIC ACID IN RAT-LIVER [J].