EFFICACY OF A SINGLE-LEAD UNIPOLAR TRANSVENOUS DEFIBRILLATOR COMPARED WITH A SYSTEM EMPLOYING AN ADDITIONAL CORONARY SINUS ELECTRODE - A PROSPECTIVE, RANDOMIZED STUDY

被引:33
作者
KUDENCHUK, PJ
BARDY, GH
DOLACK, GL
POOLE, JE
MEHRA, R
JOHNSON, G
机构
[1] Department of Medicine, Division of Cardiology, University of Washington, Seattle, WA
[2] Division of Cardiology RG-22, University of Washington, Seattle
关键词
FIBRILLATION; TACHYCARDIA; DEFIBRILLATION;
D O I
10.1161/01.CIR.89.6.2641
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Recent development of a prototype single-lead unipolar transvenous defibrillator offers the possibility of device implantation with the ease of a permanent pacemaker. Lowering defibrillation energy requirements would allow for a further reduction in defibrillator generator size and enhance the feasibility of pacemaker-like placement. However, if achieving a lower defibrillation energy requires placing additional intracardiac leads, the potential advantage of a smaller generator may be offset by the disadvantages of a more complex lead system. The purpose of this study was to compare defibrillation energy requirements of a single-lead unipolar defibrillator with a three-electrode system employing an additional lead in the coronary sinus. Methods and Results Testing of a single-lead unipolar biphasic pulse defibrillation system versus a three-electrode system with an additional coronary sinus lead was performed in prospective, randomized fashion in 15 patients with a history of ventricular tachycardia or fibrillation. Ventricular fibrillation was induced with alternating current, and defibrillation threshold was measured by a pulse given 10 seconds after arrhythmia induction. The mean defibrillation threshold stored energy and mean leading edge voltage did not significantly differ between the two systems (11.3+/-5.9 J versus 9.9+/-5.2 J and 418+/-118 V versus 390+/-112 V, respectively; P>.4). Using either defibrillation system, all patients were successfully defibrillated by <24 J and over half of patients by <10 J. Conclusions A unipolar transvenous biphasic defibrillation system is an effective means of treating ventricular fibrillation. The added complexity of additional leads is not offset by any significant improvement in defibrillation efficacy or energy requirements. Given the simplicity and effectiveness of a single-lead system coupled with a small generator, placement of defibrillation systems may now approach the ease of pacemaker implantation.
引用
收藏
页码:2641 / 2644
页数:4
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