SISTER-CHROMATID EXCHANGES AND THEIR DISTRIBUTION IN HUMAN-LYMPHOCYTES IN RELATION TO AGE, SEX AND SMOKING

被引：45

作者：

LAZUTKA, JR ^{[1
]}

DEDONYTE, V ^{[1
]}

KRAPAVICKAITE, D ^{[1
]}

机构：

[1] INST MATH & INFORMAT,VILNIUS 2600,LITHUANIA

来源：

MUTATION RESEARCH | 1994年 / 306卷 / 02期

关键词：

SISTER-CHROMATID EXCHANGE; HUMAN LYMPHOCYTES; AGE; SEX; SMOKING; CELL PROLIFERATION KINETICS;

D O I：

10.1016/0027-5107(94)90028-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The effects of age, sex and smoking on sister-chromatid exchange (SCE) frequency and distribution in human lymphocytes were assessed by means of multiple linear regression. Differences in SCE scores were associated with all above variables: SCE increased with age and cigarette smoking intensity, and higher SCE frequencies were observed in females. Changes in SCE distribution were associated with age and smoking: the ratio of sample variance to sample mean (heterogeneity index) increased with age and smoking intensity. Cell proliferation kinetics, as measured by replication index, inversely correlated with age. Monte Carlo methods were used to show that in the occupational study, analysis of 20-50 persons per group and 25 cells per person may be recommended.

引用

页码：173 / 180

页数：8

共 22 条

[1]

[Anonymous], 1988, SAS STAT USERS GUIDE

[2] CHROMOSOMAL ABERRATION AND SISTER-CHROMATID EXCHANGE FREQUENCIES IN PERIPHERAL-BLOOD LYMPHOCYTES OF A LARGE HUMAN-POPULATION SAMPLE [J].