METABOLISM OF STEROLS OF VARYING RING UNSATURATION AND METHYLATION BY CAENORHABDITIS-ELEGANS

被引:17
作者
LOZANO, R
SALT, TA
CHITWOOD, DJ
LUSBY, WR
THOMPSON, MJ
机构
[1] USDA ARS, BELTSVILLE AGR RES CTR, INSECT & NEMATODE HORMONE LAB, BLDG 467, BARC E, BELTSVILLE, MD 20705 USA
[2] UNIV MARYLAND, DEPT BOT, COLLEGE PK, MD 20742 USA
关键词
D O I
10.1007/BF02534858
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The metabolism of three dietary 4,4-desmethylsterols and two 4.alpha.-methylsterols was investigated in the free-living nematode Caenorhabditis elegans. Dietary cholestanol was converted mostly to lathosterol. Dietary lathostanol, 7-dehydrocholesterol, 4.alpha.-methylcholest-7-enol and 4.alpha.-methylcholest-8(14)-enol each remained largely unchanged. An absolute requirement for a substantial quantity of 7-dehydrocholesterol in C. elegans did not exist. C. elegans was unable to remove a 4.alpha.-methyl group or introduce a double bond at C-5 and also demonstrated the lack of a .DELTA.7-reductase. Its nutritional sterol requirement was satisfied by cholestanol, lathosterol or 7-dehydrocholesterol; growth was comparable to that obtained previously in media containing .DELTA.5-sterols. However, the two 4.alpha.-methylsterols appeared to be unsatisfactory sterol nutrients. The possible physiological importance of 4.alpha.-methylsterols is discussed briefly.
引用
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页码:84 / 87
页数:4
相关论文
共 20 条
[1]   STEROLS IN ASCARIS-LUMBRICOIDES (NEMATODA), MACRACANTHORHYNCHUS-HIRUDINACEUS AND MONILIFORMIS-DUBIUS (ACANTHOCEPHALA), AND ECHINOSTOMA-REVOLUTUM (TREMATODA) [J].
BARRETT, J ;
CAIN, GD ;
FAIRBAIRN, D .
JOURNAL OF PARASITOLOGY, 1970, 56 (05) :1004-+
[2]  
BOLLA R, 1979, J NEMATOL, V11, P250
[3]  
CHITWOOD DJ, 1986, J NEMATOL, V18, P9
[4]  
CHITWOOD DJ, 1985, J NEMATOL, V17, P64
[5]   NOVEL NUCLEAR METHYLATION OF STEROLS BY THE NEMATODE CAENORHABDITIS-ELEGANS [J].
CHITWOOD, DJ ;
LUSBY, WR ;
LOZANO, R ;
THOMPSON, MJ ;
SVOBODA, JA .
STEROIDS, 1983, 42 (03) :311-319
[6]   STEROL-METABOLISM IN THE NEMATODE CAENORHABDITIS-ELEGANS [J].
CHITWOOD, DJ ;
LUSBY, WR ;
LOZANO, R ;
THOMPSON, MJ ;
SVOBODA, JA .
LIPIDS, 1984, 19 (07) :500-506
[7]  
CHITWOOD DJ, IN PRESS COMP BIOCH
[8]  
CHITWOOD DJ, IN PRESS LIPID INTER
[9]  
CLARK AJ, 1959, J BIOL CHEM, V234, P2583
[10]   STEROL METABOLISM IN TURBATRIX ACETI [J].
COLE, RJ ;
KRUSBERG, LR .
LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY, 1968, 7 (14P2) :713-&