ACETYLCHOLINE-RECEPTOR GENE-EXPRESSION IN EXPERIMENTAL AUTOIMMUNE MYASTHENIA-GRAVIS

被引：21

作者：

ASHER, O

NEUMANN, D

WITZEMANN, V

FUCHS, S

机构：

[1] WEIZMANN INST SCI,DEPT CHEM IMMUNOL,IL-76100 REHOVOT,ISRAEL

[2] MAX PLANCK INST MED RES,ZELLPHYSIOL ABT,W-6900 HEIDELBERG 1,GERMANY

来源：

FEBS LETTERS | 1990年 / 267卷 / 02期

关键词：

Adult and embryonic acetylcholine receptor; Experimental autoimmune myasthenia gravis; Subunit transcript;

D O I：

10.1016/0014-5793(90)80932-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acetylcholine receptor (AChR) gene expression was analyzed in experimental autoimmune myasthenia gravis (EAMG) in rabbits, rats and mice. An increase in AChR transcripts was demonstrated to be exclusively associated with myasthénie symptoms and with a severe loss in membrane AChR. An increase of α-, β-, ε{lunate}-, and δ-subunit specific mRNAs (5.2-, 1.6-, 3.2- and 3.7-fold, respectively), which code for the adult type of AChR (α2βε{lunate}δ) was observed in EAMG in rats. The γ-subunit transcript was not detectable in myasthenie or healthy rats. It appears that the regulatory control of AChR gene expression in EAMG is different from that observed upon denervation. © 1990.

引用

页码：231 / 235

页数：5

共 25 条

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