DIFFERENTIAL SUPPRESSION OF INTERFERON-GAMMA-INDUCED IA-ANTIGEN EXPRESSION ON CULTURED RAT ASTROGLIA AND MICROGLIA BY 2ND-MESSENGERS

被引：34

作者：

SASAKI, A

LEVISON, SW

TING, JPY

机构：

[1] UNIV N CAROLINA,LINEBERGER CANC RES CTR,SCH MED,CB 7295,ROOM 209,CHAPEL HILL,NC 27599

[2] UNIV N CAROLINA,DEPT MICROBIOL IMMUNOL,CHAPEL HILL,NC 27599

[3] UNIV N CAROLINA,DEPT CURRICULUM NEUROBIOL,CHAPEL HILL,NC 27599

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1990年 / 29卷 / 1-3期

关键词：

Astroglia; Cyclic AMP; Ia antigen; Interferon-γ; Microglia; Protein kinase C;

D O I：

10.1016/0165-5728(90)90164-I

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The roles of intracellular second messengers in interferon-γ (IFN-γ)-induced Ia antigen (Ag) expression by astroglia and microglia were examined. Ia Ag on both glia types was induced by IFN-γ. Reagents known to increase intracellular cAMP or activate intracellular protein kinase C (PKC) reduced IFN-γ-induced Ia Ag expression by astroglia. In contrast, increasing intracellular cAMP had no suppressive effect on Ia Ag expression by microglia. These results indicate (1) cAMP and PKC negatively regulate IFN-γ-induced Ia expression on astroglia, and (2) Ia expression is regulated differentially in astroglia vs. microglia. These findings may explain the frequent observation of Ia+ microglia (or macrophages) but not astroglia in various neurodegenerative diseases. © 1990.

引用

页码：213 / 222

页数：10

共 49 条

[1]

Aguet M, 1983, Interferon, V5, P1

[2] CELLULAR-LOCALIZATION OF CYCLIC-NUCLEOTIDE CHANGES IN RAT SUPERIOR CERVICAL-GANGLION [J].