ULTRASTRUCTURAL-CHANGES IN THE OUTER HAIR-CELLS OF THE GUINEA-PIG COCHLEA AFTER EXPOSURE TO QUININE

The outer hair cells have been shown to have motile properties which are likely to participate in the cochlear performance. Quinine is known to induce hearing loss as well as contraction of skeletal muscles. Isolated outer hair cells and isolated cochlear from guinea pigs have been exposed to quinine, which was also injected into living guinea pigs. When a physiological response was registered the cells and cochlear were fixed and examined by transmission electron microscopy. In the isolated cells the formation of a central microtubule core occurred and in the cochlear a swelling of the subsurface cisternae in the outer hair cells was observed. The results are discussed in the context of a proposed effect of quinine on the contractile processes of the outer hair cells.