ANTIMALARIAL ACTIVITY OF PARTHENIN AND ITS DERIVATIVES

被引：32

作者：

HOOPER, M

KIRBY, GC

KULKARNI, MM

KULKARNI, SN

NAGASAMPAGI, BA

ONEILL, MJ

PHILLIPSON, JD

ROJATKAR, SR

WARHURST, DC

机构：

[1] UNIV LONDON, SCH PHARM, LONDON WC1N 1AX, ENGLAND

[2] UNIV LONDON LONDON SCH HYG & TROP MED, LONDON WC1E 7HT, ENGLAND

[3] NATL CHEM LABS, Pune 411008, INDIA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 25卷 / 09期

关键词：

PARTHENIN; PARTHENIN ADDUCTS; ANTIMALARIAL ACTIVITY; STRUCTURE-ACTIVITY RELATIONSHIPS;

D O I：

10.1016/0223-5234(90)90190-E

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Parthenin and some of its derivatives have been shown to posses significant anti-malarial activity against a multi-drug resistant strain of Plasmodium falciparum. Structure-activity relationships in this series of compounds are discussed and possible mechanisms of action considered. Molecular matching of the oxygen atoms of parthenin and the new anti-malarial drug qinghaosu shows both molecules to be amphipathic with common areas for their oxygen atoms and hydrocarbon frameworks.

引用

页码：717 / 723

页数：7

共 31 条

[1] ISOLATION OF ARTEMISININ (QINGHAOSU) AND ITS SEPARATION FROM ARTEMISITENE USING THE ITO MULTILAYER COIL SEPARATOR-EXTRACTOR AND ISOLATION OF ARTEANNUIN-B
ACTON, N
KLAYMAN, DL
ROLLMAN, IJ
NOVOTNY, JF
[J]. JOURNAL OF CHROMATOGRAPHY, 1986, 355 (02): : 448 - 450
[2] ARTEMISITENE, A NEW SESQUITERPENE LACTONE ENDOPEROXIDE FROM ARTEMISIA-ANNUA
ACTON, N
KLAYMAN, DL
[J]. PLANTA MEDICA, 1985, 51 (05) : 441 - 442
[3] BHAT UG, 1988, INDIAN J CHEM B, V27, P989
[4] BHAT UG, 1989, IN PRESS INDIAN J CH
[5] THE EFFECT OF COMBINATIONS OF QINGHAOSU (ARTEMISININ) WITH STANDARD ANTIMALARIAL-DRUGS IN THE SUPPRESSIVE TREATMENT OF MALARIA IN MICE
CHAWIRA, AN
WARHURST, DC
ROBINSON, BL
PETERS, W
[J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1987, 81 (04) : 554 - 558
[6] INVITRO SENSITIVITY OF NAEGLERIA-FOWLERI TO QINGHAOSU AND DIHYDROQINGHAOSU
COOKE, DW
LALLINGER, GJ
DURACK, DT
[J]. JOURNAL OF PARASITOLOGY, 1987, 73 (02) : 411 - 413
[7] QUANTITATIVE ASSESSMENT OF ANTI-MALARIAL ACTIVITY INVITRO BY A SEMIAUTOMATED MICRODILUTION TECHNIQUE
DESJARDINS, RE
CANFIELD, CJ
HAYNES, JD
CHULAY, JD
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1979, 16 (06) : 710 - 718
[8] THE CHEMOTHERAPY OF RODENT MALARIA .39. ULTRASTRUCTURAL-CHANGES FOLLOWING TREATMENT WITH ARTEMISININE OF PLASMODIUM-BERGHEI INFECTION IN MICE, WITH OBSERVATIONS OF THE LOCALIZATION OF [H-3]-DIHYDROARTEMISININE IN P-FALCIPARUM INVITRO
ELLIS, DS
LI, ZL
GU, HM
PETERS, W
ROBINSON, BL
TOVEY, G
WARHURST, DC
[J]. ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1985, 79 (04): : 367 - 374
[9] EMERSON MT, 1966, TETRAHEDRON LETT, P6151
[10] AN IMPROVED TECHNIQUE FOR THE CULTIVATION OF PLASMODIUM-FALCIPARUM INVITRO WITHOUT DAILY MEDIUM CHANGE
FAIRLAMB, AH
WARHURST, DC
PETERS, W
[J]. ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1985, 79 (04): : 379 - 384

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