DIMETHYLSULFOXIDE (DMSO) BLOCKS CONDUCTION IN PERIPHERAL-NERVE C-FIBERS - A POSSIBLE MECHANISM OF ANALGESIA

被引:65
作者
EVANS, MS
REID, KH
SHARP, JB
机构
[1] UNIV LOUISVILLE,HLTH SCI CTR,SCH MED,DEPT ANAT & NEUROBIOL,LOUISVILLE,KY 40202
[2] UNIV LOUISVILLE,HLTH SCI CTR,SCH MED,DEPT VET MED,LOUISVILLE,KY 40202
关键词
DIMETHYLSUFLOXIDE; ANALGESIA; PAIN; C-FIBER; NERVE BLOCK;
D O I
10.1016/0304-3940(93)90522-M
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Dimethylsulfoxide (DMSO) is readily absorbed through skin, and relieves musculoskeletal pain when applied topically to painful areas. We studied the effects of DMSO on C-type nerve fibers, which mediate pain sensation. DMSO was applied directly to exposed cat sural nerves. C fiber conduction velocity was slowed by DMSO, even in low concentrations (5-7% v/v). Higher concentration. completely blocked C fiber conduction, with a minimum blocking concentration of 9%. Onset of nerve block was almost immediate with 15% DMSO or higher concentrations. C fiber blockade may account for analgesia with DMSO.
引用
收藏
页码:145 / 148
页数:4
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