EVOLUTION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II ALLELIC DIVERSITY - DIRECT DESCENT IN MICE AND HUMANS

被引：45

作者：

LUNDBERG, AS ^{[1
]}

MCDEVITT, HO ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,DEPT CHEM,STANFORD,CA 94305

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 14期

关键词：

D O I：

10.1073/pnas.89.14.6545

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The high degree of polymorphism seen at major histocompatibility complex (MHC) class H loci is a feature unique to the MHC. Most of the beta-chain polymorphism is localized in "hypervariable" regions (HVRs). HVR amino acid sequence similarity between distantly related species has recently been found. We have employed a Monte-Carlo statistic to show that shared HVR polymorphism between beta-chain genes of humans and mice represents direct descent of ancestral sequences rather than convergent evolution. Furthermore, half the sequence polymorphism seen in class II beta-chain genes of mice persists in evolution and is encoded by the same DNA sequence in humans. No evidence for increased mutation rate within the HVR was found. We postulate that the HVR can be considered the genetic unit of recombination, with selection for HVR sequences and combinations of HVRs constrained by functional considerations.

引用

页码：6545 / 6549

页数：5

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