EFFECTS OF A POSITIVELY CHARGED BIOMATERIAL FOR DERMAL AND SUBCUTANEOUS AUGMENTATION

被引：47

作者：

EPPLEY, BL

SUMMERLIN, DJ

PREVEL, CD

SADOVE, AM

机构：

来源：

AESTHETIC PLASTIC SURGERY | 1994年 / 18卷 / 04期

关键词：

DERMIS; SUBCUTANEOUS AUGMENTATION; INJECTION; DEXTRAN-BASED BIOMATERIAL;

D O I：

10.1007/BF00451350

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Based on previous experimental connective tissue work, the use of a positively charged dextran-based biomaterial in subcutaneous tissue sites was evaluated. After hydration with saline, the biomaterial was injected beneath the abdominal skin in rats. A robust macrophage response was initially seen at 30 days without acute inflammation. By one year postoperatively, extensive intermaterial fibroblast and collagen ingrowth had occurred. No evidence of a foreign-body or chronic inflammatory response was seen. These preliminary findings suggest good tissue compatibility of this biomaterial and suggests that when combined with a biocompatible liquid medium, the potential for development of a bioactive dermal and subcutaneous injectable substance exists.

引用

页码：413 / 416

页数：4

共 10 条

[1]

Anderson J.M., Miller K.M., Biomaterial biocompatibility and the macrophages, Biomaterials, 5, pp. 5-10, (1984)

[2]

Eppley B.L., Sadove A.M., A physicochemical approach to improving free fat graft survival: preliminary observations, Aesth Plast Surg, 15, pp. 215-220, (1991)

[3]

Eppley B.L., Sidner R.A., Platis J.M., Sadove A.M., Bioactivation of free-fat transfers: a potential new approach to improving graft survival, Plast Reconstr Surg, 90, pp. 1022-1028, (1992)

[4]

Eppley B.L., Snyders R.V., Winkelmann T., Delfino J.J., Autologous facial fat transplantation: improved graft maintenance by microbead bioactivation, J Oral Maxillofac Surg, 50, pp. 477-452, (1992)

[5]

Krukowski M., Eppley B., Mustoe T., Osdoby P., Hard and soft connective tissue growth and repair in response to charged surfaces, Bone-Biomaterials Interface, pp. 275-284, (1991)

[6]

Mustoe T.A., Weber D.A., Krukowski M., Enhanced healing of cutaneous wounds in rats using beads with positively charged surfaces, Plast Reconstr Surg, 89, pp. 891-899, (1992)

[7]

Orida N., Feldman J.D., Directional protrusive pseudopodial activity and motility in macrophages induced by extracellular electric fields, Cell Motil, 2, pp. 243-249, (1982)

[8]

Tabata Y., Ikada Y., Effect of the size and surface charge of polymer microspheres on their phagocytosis by macrophage, Biomaterials, 9, pp. 356-362, (1988)

[9]

Vince D.G., Hunt J.A., Willia D.F., Quantitative assessment of the tissue response to implanted biomaterials, Biomaterials, 12, pp. 731-736, (1991)

[10]

Ziats N.P., Miller K.M., Anderson J.M., In vitro and in vivo interactions of cells with biomaterials, Biomaterials, 9, pp. 5-13, (1988)

← 1 →