FRONTAL-LOBE DYSFUNCTION IN SCHIZOPHRENIA AND OBSESSIVE-COMPULSIVE DISORDER - A NEUROPSYCHOLOGICAL STUDY

被引：131

作者：

ABBRUZZESE, M ^{[1
]}

BELLODI, L ^{[1
]}

FERRI, S ^{[1
]}

SCARONE, S ^{[1
]}

机构：

[1] HOSP SAN RAFFAELE,IRCCS,MILAN,ITALY

来源：

BRAIN AND COGNITION | 1995年 / 27卷 / 02期

关键词：

D O I：

10.1006/brcg.1995.1017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Converging evidence suggests there is a specific role of dorso-lateral-prefrontal cortex (DLPC) in schizophrenic disorders and of orbite-frontal cortex (OFC) in obsessive-compulsive disorder (OCD). Here, 25 schizophrenic and 25 OCD patients were evaluated with Wisconsin Card Sorting Test and Object Alternation Test; neuropsychological tools sensitive to DLPC and OFC damage, respectively; and compared with 25 subjects of a control group. Moreover, they all underwent Weigl's Sorting Test and the Word Fluency Test to assess global frontal functioning. The results indicated a DLPC deficit in schizophrenia and an OFC involvement in OCD. These data suggest that functional disorders of the central nervous system can be explored with neuropsychological instruments. (C) 1995 Academic Press. Inc.

引用

页码：202 / 212

页数：11

共 57 条

[1] PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX
ALEXANDER, GE
DELONG, MR
STRICK, PL
[J]. ANNUAL REVIEW OF NEUROSCIENCE, 1986, 9 : 357 - 381
[2] *AM PSYCH ASS, 1987, DSM III R DIAGN STAT
[3] ANDREASEN N, 1986, ARCH GEN PSYCHIAT, V43, P136
[4] [Anonymous], 1978, MULTILINGUAL APHASIA
[5] BAXTER LR, 1987, ARCH GEN PSYCHIAT, V44, P211
[6] FRONTAL AND CALLOSAL NEUROPSYCHOLOGICAL PERFORMANCES IN SCHIZOPHRENIA - FURTHER EVIDENCE OF POSSIBLE ATTENTION AND MNESIC DYSFUNCTIONS
BELLINI, L
ABBRUZZESE, M
GAMBINI, O
ROSSI, A
STRATTA, P
SCARONE, S
[J]. SCHIZOPHRENIA RESEARCH, 1991, 5 (02) : 115 - 121
[7] BERMAN KF, 1988, ARCH GEN PSYCHIAT, V45, P616
[8] LATERALIZATION OF CORTICAL FUNCTION DURING COGNITIVE TASKS - REGIONAL CEREBRAL BLOOD-FLOW STUDIES OF NORMAL INDIVIDUALS AND PATIENTS WITH SCHIZOPHRENIA
BERMAN, KF
WEINBERGER, DR
[J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1990, 53 (02) : 150 - 160
[9] Bornstein R A, 1991, J Neuropsychiatry Clin Neurosci, V3, P157
[10] BRAFF DL, 1991, ARCH GEN PSYCHIAT, V48, P891

← 1 2 3 4 5 6 →