TARGETING OF COLLOIDS TO LYMPH-NODES - INFLUENCE OF LYMPHATIC PHYSIOLOGY AND COLLOIDAL CHARACTERISTICS

被引：148

作者：

HAWLEY, AE ^{[1
]}

DAVIS, SS ^{[1
]}

ILLUM, L ^{[1
]}

机构：

[1] UNIV NOTTINGHAM,DEPT PHARMACEUT SCI,NOTTINGHAM NG7 2RD,ENGLAND

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1995年 / 17卷 / 01期

关键词：

LYMPHATIC SYSTEM; LYMPH NODE; TARGETING; ROUTES OF ADMINISTRATION; COLLOIDAL CARRIER; PHYSICOCHEMICAL ASPECTS;

D O I：

10.1016/0169-409X(95)00045-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The lymphatic uptake of colloids, whether lipid or non-lipid in nature, is determined by the physiology of the lymphatic system, and the physicochemical characteristics of the colloid in question, The fate of the colloid is also determined by the route of administration, with the subcutaneous route generally considered to be most appropriate for targeting to the regional lymph nodes. With greater understanding of these factors, it will be possible to target the lymph nodes more effectively.

引用

页码：129 / 148

页数：20

共 82 条

[1]

Absolom D R, 1986, Methods Enzymol, V132, P281

[2] SUBCUTANEOUS ADMINISTRATION OF LIPOSOMES - A COMPARISON WITH THE INTRAVENOUS AND INTRAPERITONEAL ROUTES OF INJECTION [J].

ALLEN, TM ;

HANSEN, CB ;

GUO, LSS .

BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1150 (01) :9-16

[3] DIFFUSION OF UNIVALENT IONS ACROSS LAMELLAE OF SWOLLEN PHOSPHOLIPIDS [J].

BANGHAM, AD ;

STANDISH, MM ;

WATKINS, JC .

JOURNAL OF MOLECULAR BIOLOGY, 1965, 13 (01) :238-+

[4] PARTICLE SIZING AND BIOKINETICS OF INTERSTITIAL LYMPHOSCINTIGRAPHIC AGENTS [J].

BERGQVIST, L ;

STRAND, SE ;

PERSSON, BRR .

SEMINARS IN NUCLEAR MEDICINE, 1983, 13 (01) :9-19

[5]

Bergqvist L, 1984, MICROSPHERES DRUG TH, P263

[6]

BETTENDORF U, 1979, LYMPHOLOGY, V12, P66

[7] LYMPHATIC METASTASIS AND ITS TREATMENT [J].

CARR, I ;

PETTIGREW, N ;

WEINERMAN, B .

CANCER TREATMENT REVIEWS, 1987, 14 (01) :53-64

[8] ELECTRON MICROSCOPIC STUDY OF INJURED + ABNORMALLY PERMEABLE LYMPHATICS [J].

CASLEYSMITH, JR .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1964, 116 (A3) :803-+

[9]

CASLEYSMITH JR, 1982, INT REV PHYSIOL, V26, P147

[10]

CASLEYSMITH JR, 1980, LYMPHOLOGY, V13, P120

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