THE ROLE OF T-CELL RECEPTOR-BETA CHAIN GENES IN SUSCEPTIBILITY TO RHEUMATOID-ARTHRITIS

被引：25

作者：

MCDERMOTT, M

KASTNER, DL

HOLLOMAN, JD

SCHMIDTWOLF, G

LUNDBERG, AS

SINHA, AA

HSU, C

CASHIN, P

MOLLOY, MG

MULCAHY, B

OGARA, F

MCCONNELL, FI

ADAMS, C

KHAN, MA

WOLFE, F

RUBIN, LA

CLEGG, DO

HUSEBYE, D

AMOS, CI

WARD, RH

MCDEVITT, HO

机构：

[1] NIAMS, ARTHRIT & RHEUMATISM BRANCH, BETHESDA, MD USA

[2] STANFORD UNIV, STANFORD, CA 94305 USA

[3] CASE WESTERN RESERVE UNIV, CLEVELAND, OH 44106 USA

[4] UNIV KANSAS, WICHITA, KS USA

[5] UNIV TORONTO, WOMENS COLL HOSP, TORONTO, ON, CANADA

[6] UNIV UTAH, SCH MED, SALT LAKE CITY, UT USA

[7] UNIV TEXAS, MD ANDERSON CANC CTR, HOUSTON, TX USA

来源：

ARTHRITIS AND RHEUMATISM | 1995年 / 38卷 / 01期

关键词：

D O I：

10.1002/art.1780380114

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To evaluate the role of the T cell receptor beta chain locus (TCRB) in genetic susceptibility to rheumatoid arthritis (RA). Methods. Twenty-eight multiplex RA families were recruited from 3 rheumatology outpatient departments. All members were genotyped for a highly informative microsatellite (V(beta)6.7), a V(beta)12.2 SSCP marker, and a biallelic C-beta restriction fragment length polymorphism. Data were analyzed by the SIBPAL program to assess identity-by-descent in affected sib-pairs. Results. Using the V(beta)12.2 marker, there was suggestive evidence of increased sib-pair sharing (P = 0.005) in affected offspring (a P value of 0.001 is generally taken to establish linkage). Data for V(beta)6.7 and C-beta yielded significance levels of 0.06 and 0.19, respectively. Conclusion. These data suggest that a gene in or linked to the TCRB complex may confer genetic susceptibility to RA in these families. Confirmation in a larger panel of families is required.

引用

页码：91 / 95

页数：5

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