CARRAGEENAN AND DEXTRAN IN RATS

被引：3

作者：

ANDERSON, RE ^{[1
]}

WARNE, PJ ^{[1
]}

WEST, GB ^{[1
]}

机构：

[1] NE LONDON POLYTECH, DEPT APPL BIOL, LONDON E15 4LZ, ENGLAND

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1976年 / 52卷 / 1-4期

关键词：

D O I：

10.1159/000231712

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Carrageenan injected s.c. into 1 hindpaw of the rat produced an anaphylactoid reaction which prevented the same paw responding to a 2nd dose 14 days later, but did not alter the response to dextran. Dextran did not modify the response of the hindpaw to a subsequent dose of either dextran or carrageenan 14 days later. When using these models of inflammation for testing the anti-inflammatory activity of drugs, valuable extra information may be gained by adopting the cross-over technique and using both paws of each animal.

引用

页码：425 / 427

页数：3