SYNTHESIS OF PHOSPHONATES AND OLIGODEOXYRIBONUCLEOTIDES DERIVED FROM 2'-DEOXYISOGUANOSINE AND 2'-DEOXY-2-HALOADENOSINES

被引：37

作者：

SEELA, F

MERTENS, R

KAZIMIERCZUK, Z

机构：

[1] Laboratorium Für Organische Und Bioorganische Chemie, Institut Für Chemie, Universität Osnabrück, Osnabrück, D-4500

来源：

HELVETICA CHIMICA ACTA | 1992年 / 75卷 / 07期

关键词：

D O I：

10.1002/hlca.19920750716

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Oligonucleotides containing 2'-deoxyisoguanosine (1) or 2-chloro-2'-deoxyadenosine (2a) have been prepared by solid-phase synthesis. Suitably protected phosphonates 3a, 4a, and 4b as well as the phosphoramidite of 1 have been obtained from the nucleosides 1, 2a, or 2b via the (dimethylamino)methylidene derivatives 5-7. 4,4'-Dimethoxytrityl groups were introduced to yield the base-protected derivatives 8-10. Alternatively to the direct incorporation of 1 into oligonucleotides, they were also obtained by the photochemical conversion of a 2a residue within the oligonucleotide chain.

引用

页码：2298 / 2306

页数：9

共 25 条

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