IDENTIFICATION OF A TOLFENAMIC ACID METABOLITE IN THE HORSE BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：14

作者：

JAUSSAUD, P ^{[1
]}

GUIEU, D ^{[1
]}

COURTOT, D ^{[1
]}

BARBIER, B ^{[1
]}

BONNAIRE, Y ^{[1
]}

机构：

[1] LAB,F-92290 CHATENAY MALABRY,FRANCE

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 573卷 / 01期

关键词：

D O I：

10.1016/0378-4347(92)80486-A

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A tolfenamic acid metabolite, a hydroxylated product, has been identified in equine plasma and urine samples using gas chromatography-mass spectrometry in the electron-impact and chemical-ionization modes. The method also allows the qualitative monitoring of the elimination of the drug and its metabolites from plasma. The two compounds are detected up to 48 and 24 h, respectively, after a single oral administration of a 30 mg/kg dose. The simultaneous detection of the two products increases the reliability of anti-doping control analysis.

引用

页码：136 / 140

页数：5

共 5 条

[1] IDENTIFICATION OF A FLUNIXIN METABOLITE IN THE HORSE BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY [J].