EVIDENCE THAT NITRIC-OXIDE MEDIATES THE CYCLIC-GMP RESPONSE TO SYNAPTIC ACTIVITY IN THE RAT SUPERIOR CERVICAL-GANGLION

被引：33

作者：

SHENG, H

HUGHES, ML

MURAD, F

BRIGGS, CA

机构：

[1] ABBOTT LABS,NEUROSCI RES,D-47W,BLDG AP-10,ABBOTT PK,IL 60064

[2] ABBOTT LABS,SIGNAL TRANSDUCT,ABBOTT PK,IL 60064

来源：

BRAIN RESEARCH | 1992年 / 597卷 / 02期

关键词：

NITRIC OXIDE; ENDOTHELIUM-DERIVED RELAXING FACTOR; GUANOSINE CYCLIC MONOPHOSPHATE; NG-NITRO-L-ARGININE; HEMOGLOBIN; SYMPATHETIC GANGLION; NEURAL TRANSMISSION;

D O I：

10.1016/0006-8993(92)91492-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Preganglionic nerve stimulation in the rat superior cervical ganglion (SCG) caused an increase in guanosine 3':5'-cyclic monophosphate (cyclic GMP) in a Ca2+-dependent manner. This increase was inhibited by oxyhaemoglobin, and blocked stereoselectively by an inhibitor of nitric oxide synthase, N(G)-nitro-L-arginine. Thus, nitric oxide or a similar substance appears to mediate the neuronal cyclic GMP response to synaptic activity in the rat SCG.

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页码：343 / 345

页数：3

相关论文

共 19 条

[1] NADPH DIAPHORASE-POSITIVE NEURONS IN THE RAT SPINAL-CORD INCLUDE A SUBPOPULATION OF AUTONOMIC PREGANGLIONIC NEURONS [J].

ANDERSON, CR .

NEUROSCIENCE LETTERS, 1992, 139 (02) :280-284

[2] CELLULAR-LOCALIZATION OF CYCLIC-NUCLEOTIDE CHANGES IN RAT SUPERIOR CERVICAL-GANGLION [J].

ARIANO, MA ;

BRIGGS, CA ;

MCAFEE, DA .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 1982, 2 (02) :143-156

[3] NITRIC-OXIDE SYNTHETASE (NOS)-CONTAINING SYMPATHOADRENAL CHOLINERGIC NEURONS OF THE RAT IML-CELL COLUMN - EVIDENCE FROM HISTOCHEMISTRY, IMMUNOHISTOCHEMISTRY, AND RETROGRADE LABELING [J].

BLOTTNER, D ;

BAUMGARTEN, HG .

JOURNAL OF COMPARATIVE NEUROLOGY, 1992, 316 (01) :45-55

[4] NITRIC-OXIDE, A NOVEL NEURONAL MESSENGER [J].

BREDT, DS ;

SNYDER, SH .

NEURON, 1992, 8 (01) :3-11

[5] CYCLIC-NUCLEOTIDE METABOLISM IN THE SYMPATHETIC-GANGLION [J].

BRIGGS, CA ;

WHITING, GJ ;

ARIANO, MA ;

MCAFEE, DA .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 1982, 2 (02) :129-141

[6] EFFECTS OF NEURONAL-ACTIVITY ON INOSITOL PHOSPHOLIPID-METABOLISM IN THE RAT AUTONOMIC NERVOUS-SYSTEM [J].

BRIGGS, CA ;

HORWITZ, J ;

MCAFEE, DA ;

TSYMBALOV, S ;

PERLMAN, RL .

JOURNAL OF NEUROCHEMISTRY, 1985, 44 (03) :731-739

[7] POTENTIATION OF NICOTINIC TRANSMISSION IN THE RAT SUPERIOR CERVICAL SYMPATHETIC-GANGLION - EFFECTS OF CYCLIC-GMP AND NITRIC-OXIDE GENERATORS [J].

BRIGGS, CA .

BRAIN RESEARCH, 1992, 573 (01) :139-146

[8]

DEWYER MA, 1991, BIOCHEM BIOPH RES CO, V176, P1136

[9] GLUTAMATE, NITRIC-OXIDE AND CELL CELL SIGNALING IN THE NERVOUS-SYSTEM [J].

GARTHWAITE, J .

TRENDS IN NEUROSCIENCES, 1991, 14 (02) :60-67

[10] A COMPARISON OF HEMOGLOBIN AND ERYTHROCYTES AS INHIBITORS OF SMOOTH-MUSCLE RELAXATION BY THE NANC TRANSMITTER IN THE BRP AND RAT ANOCOCCYGEUS AND BY EDRF IN THE RABBIT AORTIC STRIP [J].

GILLESPIE, JS ;

SHENG, H .

BRITISH JOURNAL OF PHARMACOLOGY, 1989, 98 (02) :445-450